Cov khoom

Islet amyloid polypeptide (IAPP; tseem hu ua amylin) yog lub luag haujlwm rau islet amyloid tsim nyob rau hauv hom 2 mob ntshav qab zib mellitus, thiab IAPP-induced toxicity ntseeg tau tias yuav ua rau kom poob ntawm β-cell loj cuam tshuam nrog rau theem kawg ntawm hom 2 mob ntshav qab zib.Islet amyloid tsim kuj tseem tuaj yeem ua lub luag haujlwm hauv kev ua tsis tiav tom qab hloov pauv.IAPP yog tsim los ua prohormone, pro-islet amyloid polypeptide (proIAPP), thiab ua tiav nyob rau hauv secretory granules ntawm pancreatic β-hlwb.Cov ntaub ntawv ua tiav ib nrab ntawm proIAPP muaj nyob hauv amyloid deposits;Qhov tseem ceeb tshaj plaws yog 48-residue nruab nrab, proIAPP (1-48), uas suav nrog N-terminal pro-extension, tab sis uas tau ua tiav zoo ntawm C-terminus.Kev ua tsis tiav tuaj yeem ua lub luag haujlwm hauv islet amyloid tsim los ntawm kev txhawb kev cuam tshuam nrog sulfated proteoglycans ntawm extracellular matrix, uas, nyob rau hauv lem, txhawb kev tsim amyloid.Peb qhia tias acid fuchsin (3-(1-(4-amino-3-methyl-5-sulphonatophenyl)-1-(4-amino-3-sulphonatophenyl)methylene)cyclohexa-1,4-dienesulphonic acid), yooj yim sulfonated triphenyl methyl derivative, yog lub zog inhibitor ntawm amyloid tsim los ntawm proIAPP (1-48) nruab nrab.Qhov nyuaj triphenyl methane derivative ceev ntsuab FCF {ethyl-[4-[[4-[ethyl-[(3-sulfophenyl)methyl]amino]phenyl]-(4-hydroxy-2-sulfophenyl)methylidene]-1-cyclohexa -2,5-dienylidene]-[(3-sulfophenyl)methyl]azanium} kuj inhibits amyloid tsim los ntawm IAPP thiab cov proIAPP ua intermediate.Ob lub tebchaw inhibit kev tsim amyloid los ntawm kev sib xyaw ntawm proIAPP nruab nrab thiab cov qauv glycosaminoglycan heparan sulfate.Acid fuchsin kuj inhibits glycosaminoglycan-mediated amyloid tsim los ntawm cov laus IAPP.Lub peev xwm los tiv thaiv kev tsim amyloid tsis yog vim yog cov tshuaj sulfonated, vim sulfonated inhibitor ntawm amyloid-β, tramiprosate, tsis yog inhibitor ntawm amyloid tsim los ntawm proIAPP (1-48).