Cov khoom

Flucytosine, tseem hu ua 5-fluorocytosine lossis 5-FC, yog cov tshuaj tua kab mob hluavtaws uas feem ntau siv los kho cov kab mob fungal.Nws raug cais raws li antimetabolite, uas txhais tau hais tias nws cuam tshuam nrog cov txheej txheem metabolic ntawm cov kab mob fungal, ua rau lawv inhibition lossis tuag.Flucytosine feem ntau yog siv ua ke nrog lwm cov tshuaj tiv thaiv kab mob kom pom kev zoo.Ib qho tseem ceeb ntawm kev siv flucytosine yog nyob rau hauv kev kho mob ntawm cov kab mob fungal, tshwj xeeb tshaj yog cov kab mob Candida thiab Cryptococcus.Nws yog feem ntau siv ua ke nrog lwm cov tshuaj tua kab mob, xws li amphotericin B lossis fluconazole, txhawm rau txhim kho nws cov tshuaj tiv thaiv kab mob.Flucytosine ua haujlwm los ntawm kev nkag mus rau cov kab mob fungal thiab hloov mus rau 5-fluorouracil, cytotoxic antimetabolite.5-fluorouracil ces cuam tshuam nrog kev sib txuas ntawm fungal RNA thiab DNA, yog li inhibiting fungal kev loj hlob thiab replication.Qhov kev ua si hauv synergistic no pab mus tua cov spectral pathogens thiab nce kev kho mob tseem ceeb uas cuam tshuam rau cov neeg muaj sia nyob ib puag ncig lub hlwb thiab tus txha caj qaum.Flucytosine yog suav tias yog ib qho ntawm thawj kab kev kho mob ua ke nrog amphotericin B rau kev kho mob ntawm tus mob no.Kev sib xyaw ua ke pab kom kov yeej cov kev txwv ntawm txhua yam tshuaj ib leeg thiab ua tiav cov txiaj ntsig kho ntau dua.Flucytosine nce mus txog qib txaus nyob rau hauv cov kua cerebrospinal, tso cai rau nws ua tau zoo rau cov kab mob fungal nyob rau hauv nruab nrab paj hlwb.Txawm li cas los xij, nws txoj kev siv yuav raug txwv vim muaj kev pheej hmoo ntawm kev txhim kho kev tiv thaiv, vim tias cov fungus tuaj yeem tau txais kev hloov pauv uas ua rau nws tsis tshua muaj kev cuam tshuam rau cov tshuaj.Kev soj ntsuam ze thiab kev soj ntsuam ib ntus ntawm cov lus teb kho mob yog qhov tseem ceeb thaum siv flucytosine los xyuas kom meej cov txiaj ntsig kev kho mob tsim nyog.Txawm hais tias flucytosine feem ntau ua tau zoo, nws tuaj yeem muaj qee yam kev phiv.Cov kev mob tshwm sim feem ntau muaj xws li mob plab hnyuv, xws li xeev siab, ntuav, thiab raws plab.Nws tseem tuaj yeem ua rau cov pob txha pob txha tawg, uas tuaj yeem ua rau cov qe ntshav qis.Kev kuaj ntshav tsis tu ncua feem ntau ua los saib xyuas cov ntshav suav thaum lub sijhawm kho mob. Hauv qhov xaus, flucytosine yog cov tshuaj tiv thaiv kab mob uas siv hauv kev sib xyaw ua ke rau kev kho cov kab mob fungal, tshwj xeeb yog cov kab mob Candida thiab Cryptococcus.Nws ua los ntawm kev cuam tshuam nrog fungal nucleic acid synthesis, inhibiting lawv txoj kev loj hlob thiab rov ua dua tshiab.Flucytosine feem ntau yog siv ua ke nrog lwm cov tshuaj tua kab mob thiab tshwj xeeb tshaj yog tseem ceeb hauv kev kho mob Cryptococcus neoformans meningitis.Txawm li cas los xij, nws txoj kev siv yuav tsum tau ua tib zoo saib xyuas vim muaj kev pheej hmoo ntawm kev tiv thaiv thiab muaj peev xwm cuam tshuam.