Cov khoom

N(ε)-trifluoroacetyl-L-lysine yog ib qho derivative ntawm cov amino acid lysine, qhov twg epsilon (ε) amino pawg tiv thaiv los ntawm ib pawg trifluoroacetyl (TFA).Qhov sib xyaw no pom cov ntawv thov hauv ntau qhov chaw, tshwj xeeb tshaj yog nyob rau hauv peptide synthesis thiab biochemical kev tshawb fawb.Ib qho loj siv N(ε)-trifluoroacetyl-L-lysine yog nyob rau hauv solid-phase peptide synthesis (SPPS).Peptides ua lub luag haujlwm tseem ceeb hauv ntau cov txheej txheem lom neeg, thiab lawv cov synthesis yuav tsum tau sib sau ua ke ntawm cov amino acids.TFA tiv thaiv pab pawg ntawm epsilon amino pawg ntawm lysine tiv thaiv kev tsis xav tau thaum lub sij hawm peptide daim ntawv cog lus thaum tso cai rau lwm cov amino acids rau ob peb ntawm qhov xav tau txoj haujlwm.Thaum peptide sib dhos ua tiav, TFA pab pawg tiv thaiv tuaj yeem raug xaiv tshem tawm, thiab N(ε)-trifluoroacetyl-L-lysine residue tuaj yeem txuas ntxiv mus rau kev sib txuas tshwj xeeb peptide sequences.N(ε)-trifluoroacetyl-L-lysine kuj yog. siv hauv kev tshawb fawb biochemical los kawm txog cov qauv protein, kev ua haujlwm, thiab kev sib cuam tshuam.Nws tuaj yeem ua lub luag haujlwm los tshawb xyuas lub luag haujlwm ntawm lysine residues hauv kev sib cuam tshuam ntawm cov protein-protein, kev sib cuam tshuam ntawm cov protein-DNA, thiab kev hloov pauv tom qab.Los ntawm kev qhia cov pab pawg TFA, cov khoom siv tshuaj lom neeg ntawm lysine tuaj yeem hloov kho, tso cai rau kev tshawb xyuas cov txheej txheem lysine-mediated hauv cov kab ke lom neeg. Tsis tas li ntawd, N(ε)-trifluoroacetyl-L-lysine tuaj yeem pom daim ntawv thov hauv kev txhim kho cov phiaj xwm. tshuaj xa tshuaj.Los ntawm kev sib txuas cov tshuaj kho tshwj xeeb rau cov lysine residue los ntawm TFA pawg, nws muaj peev xwm ua kom muaj kev ruaj ntseg thiab kev xaiv ntawm cov tshuaj, ua rau kev txhim kho kev ua tau zoo thiab txo cov kev mob tshwm sim.Cov tswv yim no tau tshawb nrhiav hauv kev xa cov tshuaj tiv thaiv kab mob, tshuaj tua kab mob, thiab lwm yam kev kho mob. Ntxiv rau nws cov kev siv ncaj qha, N(ε)-trifluoroacetyl-L-lysine tuaj yeem siv los ua lub tsev thaiv rau kev sib txuas ntawm lwm cov khoom siv ua haujlwm. .Nws cov qauv tshuaj lom neeg tshwj xeeb thiab kev ua haujlwm ua rau nws yog ib qho khoom siv zoo nkauj los yog nruab nrab rau kev sib txuas ntawm cov organic molecules, nrog rau cov tshuaj, agrochemicals, thiab cov ntaub ntawv.Txawm li cas los xij, nws yog ib qho tseem ceeb heev rau kev lis N(ε)-trifluoroacetyl-L-lysine nrog kev saib xyuas, ua raws li kev ceev faj txog kev nyab xeeb.Nws raug nquahu kom ua haujlwm hauv chav ntsuas cua kom zoo thiab siv cov cuab yeej tiv thaiv tus kheej tsim nyog, xws li hnab looj tes thiab tsom iav kev nyab xeeb.Nyob rau hauv cov ntsiab lus, N(ε)-trifluoroacetyl-L-lysine yog ib qho txiaj ntsig zoo ntawm lysine uas pom muaj ntau yam kev siv hauv peptide. synthesis, tshawb fawb biochemical, tsom xa tshuaj, thiab organic synthesis.Nws lub peev xwm los tiv thaiv epsilon amino pawg ntawm lysine tso cai rau cov peptide synthesis meej, thaum nws hloov kho cov khoom ua kom txoj kev tshawb fawb ntawm cov txheej txheem lysine-mediated.Thaum ua haujlwm zoo, N(ε)-trifluoroacetyl-L-lysine ua pov thawj tias yog ib qho cuab yeej siv tau zoo hauv ntau yam kev siv txuj ci thiab kev lag luam.