Cytidine Cas: 65-46-3 Dawb crystalline hmoov 99%
| Catalog Number | xwm 90586 |
| Khoom npe | Cytidine |
| CAS | 65-46-3 |
| Molecular Formula | C9H13N3O5 |
| Molecular Luj | 243.22 Nws |
| Cov ntaub ntawv khaws cia | Ambient |
| Harmonized tariff Code | 293499 0 |
Khoom Specification
| Qhov tshwm sim | Dawb crystalline hmoov |
| Assay | 99% |
| Cov hlau hnyav | <20 ppm |
| Tshuaj Formula | C9H13N3O5 |
| Poob rau ziab | <0.5% |
| Residue ntawm Ignition | <0.10% |
Cellular mov ntawm deoxynucleoside triphosphates (dNTPs) yog qhov tseem ceeb rau DNA replication thiab kho.Hauv txoj kev tshawb no, peb tau tshawb xyuas lub luag haujlwm ntawm CMP / UMP kinase (CMPK), ib qho enzyme catalyzes CDP tsim, hauv DNA kho.Knockdown ntawm CMPK ncua DNA kho thaum lub sij hawm rov qab los ntawm UV puas nyob rau hauv cov ntshav-deprived hlwb tab sis tsis nyob rau hauv lub hlwb tsis muaj serum deprivation.Exogenous mov ntawm cytidine los yog deoxycytidine pab txhawb DNA kho nyob ntawm CMPK nyob rau hauv cov ntshav-deprived hlwb, qhia hais tias cov synthesis ntawm dCDP los yog CDP txiav txim tus nqi kho.Txawm li cas los xij, CMPK knockdown tsis cuam tshuam rau lub xeev khov kho theem ntawm dCTP hauv cov hlwb uas tsis muaj ntshav.Tom qab ntawd peb pom qhov chaw ntawm CMPK ntawm DNA puas qhov chaw thiab nws txoj kev tsim nrog Tip60 thiab ribonucleotide reductase.Peb qhov kev soj ntsuam tau pom tias N-terminal 32-amino-acid ntawm CMPK yog qhov yuav tsum tau ua rau nws nrhiav neeg ua haujlwm rau DNA puas qhov chaw nyob rau hauv Tip60-dependent yam.Rov hais dua ntawm hom tsiaj qus tab sis tsis yog N-terminus deleted CMPK rov ua haujlwm ntawm DNA kho hauv CMPK knockdown hlwb.Peb tau thov tias qhov chaw tshwj xeeb dCDP tsim los ntawm CMPK muab ib txoj hauv kev los pab txhawb DNA kho hauv cov hlwb uas tsis muaj ntshav.
