Cyclosporin A CAS: 59865-13-3 Dawb crystalline hmoov 99%
| Catalog Number | xwm 90346 |
| Khoom npe | Cyclosporin A |
| CAS | 59865-13-3 |
| Molecular Formula | C62H111N11O12 |
| Molecular Luj | 1202.61 Nws |
| Cov ntaub ntawv khaws cia | 2 txog 8 ° C |
| Harmonized tariff Code | 29419000 ib |
Khoom Specification
| Assay | 99% |
| Qhov tshwm sim | Dawb crystalline hmoov |
| Qib | USP 35 |
| impurity | Tag nrho cov impurities: 0.6% max, Max Ib qho impurities: 0.2% |
| Cov hlau hnyav | 20 ppm max |
| Acetone | 10 ppm |
| Poob rau ziab | 2.0% max |
| Cia Kub | +4% |
| Qhov tshwm sim ntawm kev daws teeb meem | Kev daws raws li qhov tshwj xeeb hauv EPIV |
| Petroleum ether soluble tshuaj | 31 ppm |
Khoom: Dawb los yog dawb-dawb hmoov, tsw tsw thiab tasteless.Nws yog yooj yim soluble nyob rau hauv methanol, ethanol los yog acetonitrile, yooj yim soluble nyob rau hauv ethyl acetate, soluble nyob rau hauv acetone los yog ether, thiab yuav luag insoluble nyob rau hauv dej.Qhov tshwj xeeb kev sib hloov ntawm cov khoom no yog txiav txim los ntawm cov ntaub ntawv tshuaj, thiab yaj hauv methanol los ua cov tshuaj uas muaj 10 mg rau 1 ml.Kev sib hloov tshwj xeeb yog -182 ° txog -192 °.Siv: tshawb fawb biochemical.Inhibition ntawm T cell receptor signaling txoj kev
Cov khoom no yog ib hom tshuaj tiv thaiv kab mob tshiab.Nws yog ib yam khoom cyclic polypeptide uas muaj kaum ib amino acids.Nws suppresses humoral thiab cell-xa lub cev tiv thaiv kab mob yam tsis muaj kev cuam tshuam cov pob txha pob txha thiab txo cov qe ntshav dawb.Muaj peev xwm tiv thaiv kev tsis lees paub ntawm cov ntaub so ntswg hloov pauv lossis cov khoom siv hauv Chemicalbook.Nws yog siv nyob rau hauv kev kho mob rau lub raum hloov, lub siab, lub ntsws thiab lub plawv transplantation.Tsis tas li ntawd, nws muaj qee yam kev kho mob ntawm cov kab mob autoimmune, nrog rau cov kab mob schistosomiasis, malaria, ntshav qab zib, AIDS, thiab lwm yam, nrog rau cov tshuaj tiv thaiv kab mob.
Rau kev kho mob leukemia, mob qog noj ntshav, hloov lub raum, tuberculosis, thiab lwm yam.
