Creatine phosphate disodium ntsev Cas: 922-32-7 98% daj hmoov
| Catalog Number | xwm 90171 |
| Khoom npe | Creatine phosphate disodium ntsev |
| CAS | 922-32-7 : kuv |
| Molecular Formula | C4H8N3Na2O5P · 4H2O |
| Molecular Luj | 327.14 Nws |
| Cov ntaub ntawv khaws cia | Ambient |
| Harmonized tariff Code | 29 299 000 ib |
Khoom Specification
| Qhov tshwm sim | Cov hmoov daj |
| Assay | > 98.0% min |
| Dej | <0.5% |
| Cov hlau hnyav | <5 ppm |
Cardioprotectant: Creatine phosphate yog ib qho tseem ceeb ntawm lub zog-siv tshuaj nyob rau hauv cov leeg nqaij contraction thiab metabolism.Nws yog cov tshuaj siv zog cia ntawm cov nqaij leeg thiab cov nqaij striated, thiab siv rau ATP resynthesis.Phosphocreatinedisodium yog nws cov tshuaj.Sodium Creatine Phosphate, tshuaj lub npe N-[imino(phosphono)methyl]-N-methylglycine disodium ntsev, yog ib tug cardioprotective tus neeg saib xyuas launched los ntawm Italian Ouhui Pharmaceutical Factory nyob rau hauv 1992. Daim ntawv phosphocreatine plays ntau yam tseem ceeb physiological luag hauj lwm, thiab yog dav siv. rau kev tiv thaiv myocardial nyob rau hauv cov neeg mob uas mob plawv ischemia los yog thaum lub sij hawm cardiac Chemicalbook phais, thiab rau kev kho mob ntawm cov kab mob plawv xws li plawv tsis ua hauj lwm, myocardial infarction thiab arrhythmia.Nws tuaj yeem txhim kho kev ua haujlwm ntawm lub plawv thiab lub plawv dhia sib txawv hauv cov neeg mob uas muaj ischemic cardiomyopathy.Nws tuaj yeem tsis tsuas yog muab lub zog rau cov hlwb myocardial thaum lawv raug kev txom nyem los ntawm ischemia thiab hypoxia, tab sis tseem tiv thaiv myocardial cell membranes los ntawm kev cuam tshuam ntawm oxygen dawb radicals thiab lwm yam khoom tsis zoo, uas tuaj yeem cuam tshuam rau lub plawv.Postoperative myocardial tiv thaiv nyob rau hauv cov neeg mob uas tsis muaj peev xwm valvular kab mob yog zoo rau postoperative rov qab ntawm lub plawv muaj nuj nqi nyob rau hauv cov neeg mob uas incompetent valvular kab mob.Siv nws los kho myocardial kev puas tsuaj tom qab neonatal asphyxia tuaj yeem txhim kho myocardial enzymes thiab electrocardiogram, thiab muaj cov txiaj ntsig zoo thiab kev nyab xeeb.
Cov yam ntxwv ua haujlwm Cov khoom no yog cov tshuaj siv zog cia ntawm cov hlab plawv thiab cov leeg pob txha, thiab yog siv rau resynthesis ntawm ATP, muab lub zog rau cov txheej txheem ntawm actomyosin contraction, thiab plays lub luag haujlwm tseem ceeb hauv lub zog metabolism ntawm cov leeg nqaij.Lub zog tsis txaus yog qhov tseem ceeb hauv kev tsim thiab kev loj hlob ntawm myocardial cell raug mob.
1. Nws muaj kev tiv thaiv tseem ceeb ntawm ischemic myocardial systolic muaj nuj nqi, uas tuaj yeem ua kom rov qab ua haujlwm siab thiab txo cov ntshav siab sai sai.
2. Khaws cov ntsiab lus ntawm adenosine triphosphate thiab creatine phosphate hauv cov hlwb, thiab Chemicalbook tswj cov myocardial zog cia.
3. Txo qhov poob ntawm creatine kinase thiab txo qhov kev puas tsuaj ntawm cell membrane.
4. Nws muaj anti-peroxidation zog.
5. Txhim kho myocardial microcirculation.Vim muaj lub zog phosphate bonds nyob rau hauv creatine phosphate molecules, lub zog phosphate bonds tuaj yeem ncaj qha hloov ADP rau hauv ATP raws li kev ua ntawm creatine phosphate, thiab ncaj qha muab lub zog rau lub cev ua haujlwm tam sim ntawd.Raws li cov khoom nruab nrab ntawm glycolysis, sodium fructose diphosphate yuav tsum tau ua lub luag haujlwm tsis ncaj los ntawm cov metabolism hauv anaerobic.
Synthetic txoj kev:
1 Siv dibenzyl phosphate ua raw khoom, hnov mob nrog oxalyl chloride kom tau dibenzyl oxyphosphoryl chloride,
Raws li kev ua ntawm triethylamine, dibenzyloxyphosphoryl creatine ethyl ester tau txais los ntawm cov tshuaj tiv thaiv nrog creatine ethyl ester hydrochloride yog cyclized rau dibenzyloxyphosphoryl creatinine,
3. Tom qab palladium carbon catalyzed hydrogenolysis rau debenzylate, hnov nrog sodium hydroxide kom tau disodium creatinine phosphate,
4 yog hydrolyzed rau 1 raws li kev ua ntawm sodium hydroxide.
Siv: Nws yog tsim rau kev tiv thaiv qhov txawv txav myocardial metabolism hauv lub xeev ntawm myocardial ischemia.
Cov tshuaj tiv thaiv tsis zoo, contraindications thiab tshuaj cuam tshuam: cov neeg uas ua xua rau cov khoom no raug txwv;Cov neeg uas muaj lub raum tsis txaus yog txwv tsis pub siv cov koob tshuaj loj (5-10g / d).Kev txhaj tshuaj sai ntawm ntau dua 1g tuaj yeem ua rau txo qis ntshav siab.Kev noj tshuaj ntau dhau los ua rau muaj cov phosphate ntau ntxiv, uas tuaj yeem cuam tshuam cov calcium metabolism thiab tso tawm cov tshuaj hormones uas tswj hwm homeostasis, cuam tshuam rau lub raum ua haujlwm thiab purine metabolism.
