Citicoline sodium CAS: 33818-15-4 CYTIDINE-5'-DIPHOSPHOCHOLINE
| Catalog Number | xwm 90590 |
| Khoom npe | Citicoline sodium |
| CAS | 33818-15-4 ib |
| Molecular Formula | C14H25N4NaO11P2 |
| Molecular Luj | 510.31 Nws |
| Cov ntaub ntawv khaws cia | -20 ° C |
| Harmonized tariff Code | 293499 0 |
Khoom Specification
| Qhov tshwm sim | Dawb Khoom |
| Assay | 99% |
| Melting point | 250 ° C (dec.) (lit.) |
| Boiling point | 760 hliHg |
| PSA | 238.1700 Nws |
| logP | -0.14090 |
| Solubility | H2O: 100 mg/ml |
Citicoline (CDP-choline) yog ib qho tseem ceeb intermediary hauv biosynthesis ntawm phosphatidylcholine, ib qho tseem ceeb ntawm cov neural cell membrane.Nws tau raug pom tias tsim cov txiaj ntsig zoo hauv ob qho tib si tsiaj qauv thiab tsis yog Asmeskas kev kuaj mob stroke.Txoj kev tshawb no suav nrog kev sib tw (3 koob tshuaj citicoline rau 1 placebo), tswj lub tsheb, ob qhov muag tsis pom kev sim ntawm 21 US cov chaw.Kev kho mob yuav tsum tau pib nyob rau hauv 24 teev ntawm qhov pib mob stroke thiab txuas ntxiv hais lus rau 6 lub lis piam.Qhov kev ntsuam xyuas zaum kawg yog nyob ntawm 12 lub lis piam.Ob puas tsib caug cuaj tus neeg mob tau cuv npe, nrog kwv yees li 65 ntawm txhua pawg ntawm plaub.Lub sijhawm nruab nrab ntawm qhov pib mob stroke mus rau kev kho mob yog 14.5 teev, thiab tsis muaj qhov sib txawv tseem ceeb ntawm cov yam ntxwv ntawm plaub pawg tshwj tsis yog rau cov neeg mob hnyav.Qhov sib txawv tseem ceeb ntawm cov pab pawg, nyiam citicoline kev kho mob, tau pom nyob rau hauv cov nqe lus ntawm kev ua haujlwm tau zoo raws li ntsuas los ntawm Barthel Index thiab Rankin scale, kev ntsuam xyuas neurologic raws li ntsuas los ntawm National Institutes of Health (NIH) stroke scale, thiab kev txawj ntse ua haujlwm raws li ntsuas los ntawm Mini Mental Status Examination.Thaum lub hauv paus NIH stroke scale tau siv los ua covariate, ob qho tib si 500-mg citicoline pawg thiab 2,000-mg citicoline pawg tau muaj kev txhim kho tseem ceeb ntawm feem pua ntawm cov neeg mob uas tau txais txiaj ntsig zoo ntawm Barthel Index ntawm 90 hnub.Tsis muaj tshuaj cuam tshuam txog cov xwm txheej tsis zoo lossis kev tuag hauv txoj kev tshawb no.Txoj kev tshawb no qhia tias qhov ncauj citicoline tuaj yeem siv tau yam nyab xeeb nrog cov kev mob tshwm sim tsawg kawg hauv kev kho mob stroke.Citicoline zoo li txhim kho cov txiaj ntsig kev ua haujlwm thiab txo qis cov paj hlwb nrog 500 mg ntawm citicoline zoo li koob tshuaj.
