![Bis [2-Hydroxyethyl] imino Tris-(Hydroxymethyl)-methane Cas: 6976-37-0 99% Featured duab](http://cdn.globalso.com/xdbiochems/6976-37-0.jpg)
Bis [2-Hydroxyethyl] imino Tris-(Hydroxymethyl)-methane Cas: 6976-37-0 99%
| Catalog Number | XD90111 |
| Khoom npe | BIS-TRIS (Bis (2-hydroxyethyl) amino-tris (hydroxymethyl) methane) |
| CAS | 6976-37-0 |
| Molecular Formula | C8H20 NPO 5 |
| Molecular Luj | 210.2476 ib |
| Cov ntaub ntawv khaws cia | Ambient |
| Harmonized tariff Code | 2922190090 ib |
Khoom Specification
| Cov hlau hnyav | <10ppm |
| Residue ntawm Ignition | <0.1% |
| Pka | 6.3-6.7 |
| Qhov tshwm sim | Dawb Crystalline hmoov |
| Solubility (1M hauv H20) | Ntshiab thiab ua kom tiav |
| pH (1M hauv H2O) | 9.0-11.0 Nws |
| Moisture (LOD) | 1.0% max. |
| Assay (Titration ntawm qhuav hauv paus) | 99.0% min. |
Tsis siv neeg, siv rau kev tshawb nrhiav creatine-creatinase;kuj tseem siv rau kev tiv thaiv zoo ntawm hemoglobin hauv khov-qhuav;catholyte, siv nyob rau hauv IEF / 2-D gel electrophoresis.
Glial cell line-derived neurotrophic factor (GDNF) yog ib qho muaj zog inhibitor ntawm ethanol noj thiab rov qab los, thiab GDNF heterozygous knockout nas tso tawm kom muaj nqi zog rau ethanol thiab haus ntau ethanol tom qab lub sijhawm abstinence tshaj lawv cov tsiaj qus littermates.Ntawm no, peb tau sim seb ethanol hloov GDNF kev qhia hauv thaj chaw ventral tegmental (VTA; GDNF qhov chaw ntawm kev ua) thiab / lossis cov nucleus accumbens (NAc; lub hauv paus tseem ceeb ntawm GDNF), thiab yog tias muaj, txiav txim siab lub luag haujlwm ntawm qhov kev loj hlob endogenous. nyob rau hauv kev cai ntawm ethanol noj.Kev tswj hwm ntawm ethanol nce GDNF qhia thiab qib protein ntau hauv VTA, tab sis tsis yog NAc.Tsis tas li ntawd, GDNF qib tau nce siab tom qab kev sib tham ethanol-haus dej hauv cov nas uas tau noj ethanol hauv cov txheej txheem kev nkag mus rau ob lub raj mis xaiv rau 1 lub lis piam, tab sis tsis yog 7 lub lis piam.Kev deprivation tom qab 7 lub lis piam ntawm ethanol ntau npaum li cas txo GDNF qib, thaum lub sij hawm luv luv ethanol binge haus tom qab deprivation upregulated GDNF qhia.Qhov tseem ceeb, knockdown ntawm GDNF nyob rau hauv VTA siv adenovirus qhia luv luv hairpin RNA pab txhawb kev nce ntawm ethanol haus los ntawm ethanol-naïve nas, tab sis tsis yog los ntawm nas nrog keeb kwm ntawm kev noj ethanol ntau dhau.Cov txiaj ntsig no qhia tau hais tias thaum pib qhov kev paub txog kev haus ethanol, GDNF hauv VTA tau nce thiab tiv thaiv kev txhim kho ntawm kev noj ethanol ntau dhau.Txawm li cas los xij, qhov kev loj hlob ntawm kev tiv thaiv cov lus teb rau ethanol tawg tom qab ncua kev noj ntau dhau ntawm ethanol thiab tshem tawm, ua rau tsis tu ncua, ntau dhau ntawm ethanol noj.
