BCIP-Toluidine) 5-Bromo-4-chloro-3-indolylphosphate-p-toluidine ntsev Cas: 6578-06-9 99% Dawb rau lub teeb xim av hmoov
| Catalog Number | xwm 90137 |
| Khoom npe | BCIP-Toluidine) 5-Bromo-4-chloro-3-indolylphosphate-p-toluidine ntsev |
| CAS | 6578-06-9 |
| Molecular Formula | C8H5BrClNO4P·C7H10N |
| Molecular Luj | 433.62 ib |
| Cov ntaub ntawv khaws cia | -15 rau -20 ° C |
| Harmonized tariff Code | 2933980 :ib |
Khoom Specification
| Qhov tshwm sim | Dawb / lub teeb xim av hmoov |
| Assay | ≥ 99% |
| Melting point | 194-195 ºC |
| Boiling point | 580.2 ° C ntawm 760 mmHg |
| Flash point | 304.7°C dej |
| Solubility | DMF: 20 mg/ml |
| Solubility | Soluble hauv dimethylformamide, insoluble hauv dej. |
| rhiab heev | Sensitive rau lub teeb, rhiab rau huab cua, thiab rhiab rau cua sov |
Kev ua haujlwm lom neeg: BCIP (BCIP p-toluidine ntsev; X-phosphate p-toluidine ntsev) yog ib qho chromogenic substrate rau colorimetric nrhiav tau ntawm alkaline phosphatase kev ua.
Shiga toxins (Stxs) yog tsim los ntawm enterohemorrhagic Escherichia coli (EHEC), uas ua rau tib neeg kis tau tus mob feem ntau tuag taus.Vero cell kab, muab los ntawm African ntsuab liab raum, sawv cev rau tus qauv kub rau kev txiav txim siab cytotoxic los ntawm Stxs.Txawm hais tias lawv siv thoob ntiaj teb, kev paub txog cov qauv tseeb ntawm Stx receptor glycosphingolipids (GSLs) thiab lawv cov kev sib dhos hauv lipid rafts tsis zoo.Ntawm no peb nthuav qhia cov qauv kev txheeb xyuas ntawm Stx receptor GSLs thiab lawv cov kev faib tawm rau cov ntaub so ntswg-tiv taus (DRMs), uas tau npaj los ntawm Vero-B4 hlwb thiab siv los ua lipid raft sib npaug.Peb tau txheeb xyuas globotriaosylceramide (Gb3Cer) thiab globotetraosylceramide (Gb4Cer) raws li GSL receptors rau Stx1a, Stx2a, thiab Stx2e subtypes siv TLC overlay nrhiav tau ua ke nrog MS.Qhov tsis tshua muaj Stx receptor, globopentaosylceramide (Gb5Cer, Galβ3GalNAcβ3Galα4Galβ4Glcβ1Cer), uas tau lees paub tshwj xeeb (ntxiv rau Gb3Cer thiab Gb4Cer) los ntawm Stx2e, tau ua tiav cov qauv tsim.Lipoforms ntawm Stx receptor GSLs tau pom nyob rau hauv feem ntau harbor ceramide moieties muaj li ntawm sphingosine (d18:1) thiab C24:0 / C24:1 los yog C16:0 fatty acid.Ntxiv mus, kev sib koom ua ke nrog lipid raft markers, SM thiab cov roj cholesterol, hauv DRMs pom zoo GSL koom nrog membrane microdomains.Txoj kev tshawb no muab lub hauv paus rau kev tshawb fawb ntxiv txog kev ua haujlwm ntawm lipid raft-scociated Stx receptors rau cov tshuaj lom-mediated raug mob ntawm Vero-B4 hlwb.
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