Cov khoom

Peb pawg neeg laus txiv neej cynomolgus liab (Macaca fascicularis) tau raug 200 micrograms/m3 ammonium hexachloroplatinate [(NH4)2PtCl6], 200 micrograms (NH4)2PtCl6 concurrently nrog 1 ppm ozone (Ozone nkaus xwb 1.ppm), los yogCov tsiaj raug nthuav tawm los ntawm kev nqus pa rau 6 teev hauv ib hnub, 5 hnub hauv ib lub lis piam rau 12 wk.Cov kev sim tsim muaj xws li methacholine preexposure thiab Na2PtCl6 bronchoprovocation kev sib tw kev ntsuam xyuas, Na2PtCl6 qhov pib ntawm daim tawv nqaij kuaj, thiab sera rau kev soj ntsuam cov tshuaj tiv thaiv.Ob lub lis piam tom qab 12-wk nthuav tawm, cov kev ntsuas tib yam no tau rov ntsuas dua.Lub hauv paus ua haujlwm pulmonary tsis cuam tshuam los ntawm cov txheej txheem raug;Txawm li cas los xij, kev sib xyaw ua ke ntawm kev raug O3 thiab (NH4) 2PtCl6 txo qhov concentration ntawm platinum (Pt) ntsev thiab methacholine tsim nyog kom nce qhov nruab nrab pulmonary flow resistance (RL) 200% (EC200 RL).Ozone lossis Pt raug ib leeg tsis muaj qhov cuam tshuam loj rau cov kev txwv no.Platinum thiab methacholine EC200 RL qhov tseem ceeb tau sib raug zoo rau ob pawg Pt-pom tom qab raug.Cov ntaub ntawv no tau qhia tias kev sib xyaw O3 thiab Pt raug cuam tshuam ntau ntxiv (Pt) thiab tsis tshwj xeeb (methacholine) bronchial hyperreactivity ntau dua li tau raug O3 lossis Pt ntsev ib leeg.Kev sib xyaw O3 ntxiv rau Pt raug kuj tseem ua rau muaj qhov tshwm sim ntawm Pt zoo ntawm daim tawv nqaij thaum piv nrog rau lwm pab pawg raug.Zoo ib yam li tib neeg kev paub dhau los, kev sim tshuaj radioallergosorbent (RAST) rau Pt-specific antibodies tsis yog rhiab heev li kev kuaj tawv nqaij ncaj qha hauv kev txheeb xyuas cov neeg ua xua.