Albendazole CAS 54965-21-8
| Catalog Number | xwm 91873 |
| Khoom npe | Albendazole |
| CAS | 54965-21-8 |
| Molecular Formula | C12H15N3O2S |
| Molecular Luj | 265.33 Nws |
| Cov ntaub ntawv khaws cia | 2-8 ° C |
| Harmonized tariff Code | 29332990 ib |
Khoom Specification
| Qhov tshwm sim | Dawb crystalline hmoov |
| Assay | 99% min |
| Melting point | 208-210 ° C |
| ceev | 1.2561 (kev kwv yees kwv yees) |
| Refractive Index | 1.6740 (kwv yees) |
| solubility | Xyaum insoluble hauv dej, dawb soluble nyob rau hauv anhydrous formic acid, soluble me ntsis nyob rau hauv methylene chloride, xyaum insoluble nyob rau hauv ethanol (96 ib xees). |
| pka ua | 10.72 ± 0.10 (Kev kwv yees) |
| Dej Solubility | 0.75 mg / L (209 ºC) |
Albendazole yog ib qho tshuaj siv los kho cov kab mob los ntawm cov kab mob cab.Nws tuaj yeem muab los kho mob hlwb tsis tshua muaj kab mob (neurocysticercosis) lossis nws tuaj yeem muab los kho tus kab mob cab uas ua rau mob plab tseem ceeb (microsporidiosis).
Ib tug derivative ntawm benzimidazole, albendazole yog ib tug tshuaj nrog ib tug dav antihelmintic spectrum.Nws nthuav tawm cov nyhuv antihelmintic tawm tsam rhiab heev cestodes thiab nematodes los ntawm kev thaiv cov txheej txheem ntawm cov piam thaj los ntawm cov cab, uas tau nthuav tawm hauv kev txo qis ntawm glycogen reserves thiab txo qis hauv qib ntawm adenosintriphophate.Yog li ntawd, tus kab mob no nres thiab tuag.Nws yog siv thaum kis kab mob ntawm Acaris lumbricoides, Ancylostoma duodenale, Necator americanus, Enterobius vermicularis, thiab Trichuris trichiura.Synonyms ntawm cov tshuaj no yog SKF 62979 thiab lwm yam.
Methyl 5-(propylthio)-2-benzimidazolecarbamate (Eskazole, Zentel) yog ib qho dav-spectrum anthelmintic uas tam sim no tsis tau muag hauv North America.Nws yog muaj nyob rau ntawm manufacturers ntawm ib tug compassionate siv hauv paus.Albendazole tau dav siv thoob plaws ntiaj teb rau kev kho mob ntawm cov kab mob hauv plab hnyuv.Nws muaj txiaj ntsig zoo li kev kho mob ib zaug rau ascariasis, Kab mob tshiab thiab qub ntiaj teb hookworm kab mob, thiab trichuriasis.Kev kho ntau yam nrog albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, thiab kab mob hydatid.Kev ua tau zoo ntawm albendazole tiv thaiv kab mob tapeworms (cestodes) feem ntau yog qhov sib txawv thiab tsis zoo.
Albendazole tshwm sim raws li ib tug dawb crystalline hmoov uas yog virtually insoluble nyob rau hauv dej.Lub qhov ncauj nqus ntawm albendazoleis txhim kho los ntawm kev noj zaub mov rog.Cov tshuaj no dhau mus sai thiab nthuav dav thawj zaug-dhau cov metabolism mus rau sulfoxide, uas yog daim ntawv nquag hauv plasma.Kev tshem tawm ib nrab-lub neej ntawm sulfoxide nyob ntawm 10 mus rau 15 teev.Muaj txiaj ntsig zoo rau kev tso tawm ntawm biliary excretion thiab enterohepatic recycling ntawm albendazolesulfoxide tshwm sim.Albendazole feem ntau zoo tolerated nyob rau hauv ib koob tshuaj kho rau cov hnyuv nematodes.Kev siv tshuaj ntev ntev, kev kho mob ntev yuav tsum tau siv rau kev kho mob clonorchiasis orechinococcal kab mob tuaj yeem ua rau muaj kev cuam tshuam tsis zoo xws li pob txha pob txha kev nyuaj siab, nce siab ntawm lub siab enzymes, thiab alopecia.
Albendazole muaj ntau yam kev ua haujlwm tawm tsam plab hnyuv nematodes thiab cestodes, nrog rau lub siab flukes Opisthorchis sinensis, Opisthorchis viverrini, thiab Clonorchis sinensis.Nws kuj tau siv tau zoo tiv thaiv Giardia lamblia.Albendazole yog ib qho kev kho mob zoo ntawm hydatid cyst disease (echinococcosis), tshwj xeeb tshaj yog thaum nrog praziquantel.Nws kuj tseem siv tau zoo hauv kev kho mob cerebral thiab spinal neurocysticercosis, tshwj xeeb tshaj yog thaum muab nrog dexamethasone.Albendazole tau pom zoo rau kev kho mob gnathostomiasis.
