Cov khoom

Lub histamine H4 receptor (HRH4), nrhiav pom tsuas yog 13 xyoo dhau los, suav hais tias yog lub hom phiaj zoo rau kev ua xua, o, mob autoimmune thiab mob qog noj ntshav, raws li kev cuam tshuam los ntawm cov ntaub ntawv tshawb fawb tsis tu ncua thiab daim ntawv thov patent.Txawm hais tias lub xub ntiag ntawm HRH4 tau ua pov thawj hauv qhov testis, nws qhov chaw tshwj xeeb lossis nws lub luag haujlwm tseem tsis tau tsim.Ntawm no, peb nrhiav kev txheeb xyuas qhov muaj peev xwm koom tes ntawm HRH4 hauv kev tswj hwm ntawm Leydig cell function.Peb thawj zaug soj ntsuam nws cov lus qhia hauv MA-10 Leydig qog hlwb thiab tom qab ntawd soj ntsuam cov teebmeem ntawm ob HRH4 agonists ntawm steroidogenesis thiab kev loj hlob.Peb pom tias HRH4 tau ua haujlwm tau zoo hauv MA-10 hlwb, thiab nws qhov kev ua haujlwm ua rau muaj kev cuam tshuam ntawm LH / tib neeg chorionic gonadotropin-induced cAMP ntau lawm thiab Star protein qhia.Tsis tas li ntawd, peb pom qhov txo qis ntawm cov cell proliferation tom qab 24-h HRH4 agonist kho.Tom qab ntawd peb tau kuaj xyuas qhov chaw ntawm HRH4 qhia hauv cov nas ib txwm kuaj, thiab kuaj HRH4 immunostaining hauv Leydig hlwb ntawm cov nas hnub nyoog 7-240 hnub, thaum cov nas muaj hnub nyoog 21 hnub kuj tau nthuav tawm HRH4 qhia hauv txiv neej gametes.Thaum kawg, peb tau soj ntsuam cov txiaj ntsig ntawm HRH4 kev ua kom muaj kev loj hlob ntawm ib txwm muaj progenitor thiab cov nas tsis paub qab hau Leydig kab lis kev cai ntawm tes, thiab ob qho tib si ua pov thawj tias muaj kev cuam tshuam los tiv thaiv kev loj hlob ntawm HRH4 agonists.Muab qhov tseem ceeb ntawm histamine (2-(1H-imidazol-4-yl) ethanamine) nyob rau hauv tib neeg (patho) lub cev nqaij daim tawv, kev siv zog txuas ntxiv raug coj mus rau elucidating cov khoom tshiab ntawm HRH4 thiab nws cov ligands.Txoj kev tshawb no nthuav tawm cov chaw tshiab ntawm HRH4 qhia, thiab yuav tsum tau txiav txim siab hauv kev tsim cov HRH4 agonists xaiv rau cov hom phiaj kho.