Cov khoom

Acyl-CoA tsim pib cov cellular fatty acid metabolism.Acyl-CoAs yog tsim los ntawm ligation ntawm fatty acid rau Coenzyme A kho los ntawm ib tsev neeg loj ntawm acyl-CoA synthetases (ACS).Hloov pauv, acyl-CoAs tuaj yeem hydrolyzed los ntawm tsev neeg ntawm acyl-CoA thioesterases (ACOT).Ntawm no, peb tau txiav txim siab cov kev cai hloov pauv ntawm tag nrho ACS thiab ACOT enzymes thoob plaws cov ntaub so ntswg thiab teb rau cov teeb meem metabolic.Peb pom cov qauv ntawm kev tswj hwm kev sib koom tes hauv thiab nruab nrab ntawm cov tsev neeg cov noob no nrog rau cov kev cai sib txawv uas tshwm sim hauv cov ntaub so ntswg- thiab physiologically-dependent yam.Vim pom kev hloov pauv hauv cov saw ntev ACOT mRNA thiab cov protein ntau hauv daim siab thiab cov ntaub so ntswg adipose, peb txiav txim siab qhov tshwm sim ntawm kev nce cytosolic long-chain thioesterase kev ua haujlwm ntawm fatty acid metabolism hauv cov ntaub so ntswg los ntawm kev tsim cov nas transgenic overexpressing hyperactive mutant ntawm Acot7 nyob rau hauv lub daim siab los yog adipose ntaub so ntswg.Kev ua ob npaug ntawm cytosolic acyl-CoA thioesterase kev ua tsis tiav los tiv thaiv mic e los ntawm kev noj zaub mov vim kev rog rog, rog rog lossis insulin tsis kam, txawm li cas los xij, overexpression ntawm Acot7 hauv adipocytes ua rau nas txias tsis kam.Ua ke, cov ntaub ntawv no qhia txog kev sib txawv ntawm kev tswj hwm ntawm ACS thiab ACOT enzymes thiab tias cov enzymes ua haujlwm hauv kev sib koom tes los tswj cov fatty acid metabolism hauv cov ntaub so ntswg.