5-Iodo-2′-deoxycytidine CAS: 54-42-2 98-102% Dawb crystalline hmoov
| Catalog Number | xwm 90562 |
| Khoom npe | 5-Iodo-2'-deoxycytidine |
| CAS | 54-42-2 ib |
| Molecular Formula | C9H11IN2O5 |
| Molecular Luj | 354.10 Nws |
| Cov ntaub ntawv khaws cia | 2 txog 8 ° C |
| Harmonized tariff Code | 293499 0 |
Khoom Specification
| Qhov tshwm sim | Dawb crystalline hmoov |
| Assay | 99% |
| Kev sib hloov tshwj xeeb | +25 txog +30 |
| Cov hlau hnyav | <0.001% |
| Poob rau ziab | <1.0% |
| Residue ntawm Ignition | <0.3% |
Qhov kev kwv yees 3D qauv ntawm ob-stranded DNA renders nws zoo tagnrho suited raws li ib tug qauv rau hauv qab-up tsim ntawm functionalized nucleic acid-raws li active sites.Peb nyob ntawm no tshawb nrhiav kev siv 14mer DNA duplex ua ib qho scaffold rau qhov tseeb thiab kwv yees qhov chaw ntawm catalytic functionalities.Muab kev koom tes nyob rau txhua qhov chaw ntawm histidine-based imidazole pawg hauv kev paub txog cov protein thiab cov xwm txheej catalysis, ib qho histidine-zoo li hloov duplexes tau tshawb xyuas.Tethering histamine rau C5 ntawm thymine puag ntawm amide daim ntawv cog lus, tso cai rau qhov hloov pauv ntawm imidazole muaj nuj nqi hauv qhov zawj loj.Kev sib cuam tshuam ntawm imidazole thiab duplex thiab nws cov kev cuam tshuam ntawm imidazolium pKaH raug tshawb xyuas los ntawm kev tso ib qho kev hloov kho thymine ntawm plaub txoj haujlwm sib txawv hauv nruab nrab ntawm 14mer ob chav helix.Siv NMR thiab unrestrained molecular dynamics, ib tug qauv motif uas tsim ib tug hydrogen daim ntawv cog lus ntawm lub imidazole thiab Hoogste nyob rau sab ntawm lub guanine bases ntawm ob tug nyob sib ze GC puag khub yog tsim.Lub motif pab txhawb kom ruaj khov tiv thaiv thermal melting ntawm 6 ° C thiab yog qhov tseem ceeb hauv kev hloov pauv pKaH ntawm pawg imidazolium.Cov yam ntxwv dav dav, yam yuav tsum tau ua ua ntej thiab cov cwj pwm zoo ntawm pKaH-regulating motif tshiab tau piav qhia.
