Trimethoprim Cas: 738-70-5
| Catalog Number | xwm 92385 |
| Khoom npe | Trimethoprim |
| CAS | 738-70-5 : kuv |
| Molecular Formula | C14H18N4O3 |
| Molecular Luj | 290.32 Nws |
| Cov ntaub ntawv khaws cia | 2-8 ° C |
| Harmonized tariff Code | 2933595 ib |
Khoom Specification
| Qhov tshwm sim | Cov hmoov dawb los yog daj-dawb |
| Assay | 99% min |
| Melting Point | 199-203 Deg C |
| Cov hlau hnyav | ≤ 20ppm |
| Poob rau ziab | ≤ 1.0% |
| Yam khoom muaj feem | ≤ 0.2% |
| Solubility | Soluble me ntsis hauv dej, me ntsis soluble hauv cawv, xyaum insoluble hauv ether |
Trimethoprim yog lipophilic thiab tsis muaj zog alkaline pyrimethamine class bacteriostatic tus neeg sawv cev.Nws yog dawb los yog yuav luag dawb crystalline hmoov, tsw tsw, iab, thiab me ntsis soluble nyob rau hauv chloroform, ethanol los yog acetone, tab sis yuav luag insoluble nyob rau hauv dej thiab heev soluble nyob rau hauv glacial acetic acid kua.Nws muaj cov tshuaj tua kab mob uas zoo ib yam nrog cov tshuaj sulfa, tab sis muaj cov nyhuv antibacterial muaj zog.Nws muaj cov txiaj ntsig zoo ntawm kev kho Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Staphylococcus saprophyticus, thiab ntau yam kab mob gram-zoo thiab tsis zoo.Tab sis nws tsis muaj txiaj ntsig tiv thaiv kab mob Pseudomonas aeruginosa.Nws qhov tsawg kawg nkaus inhibitory concentration yog feem ntau tsawg dua 10 mg / L nrog kev siv ib leeg ua kom yooj yim ua rau cov kab mob tsis zoo, thiab yog li nws feem ntau tsis siv ib leeg, thiab feem ntau ua ke nrog sulfa tshuaj los tsim cov tshuaj sib xyaw rau kev kho mob ntawm cov kab mob urinary, plab hnyuv. kab mob, kab mob ua pa, mob plab, enteritis, typhoid fever, meningitis, otitis media, meningitis, sepsis thiab mos mos kab mob.Nws muaj kev cuam tshuam rau kev kho mob typhoid thiab paratyphoid effect uas tsis tsawg dua ampicillin;Nws tseem tuaj yeem ua ke nrog cov tshuaj sulfa ntev ntev rau kev tiv thaiv thiab kho cov tshuaj tiv thaiv falciparum malaria.
Lub hauv paus ntsiab lus ntawm kev tiv thaiv kab mob ntawm trimethoprim yog cuam tshuam nrog folate metabolism hauv cov kab mob.Lub luag haujlwm tseem ceeb ntawm kev ua haujlwm yog kev xaiv inhibition ntawm kev ua ntawm dihydrofolate reductase hauv cov kab mob kom dihydrofolate tsis tuaj yeem txo qis rau tetrahydrofolate.Txij li thaum lub synthesis ntawm folic acid yog ib feem tseem ceeb ntawm ib tug nucleic acid biosynthesis, thiab yog li ntawd cov khoom tiv thaiv kab mob nucleic acids thiab proteins synthesis.Tsis tas li ntawd, qhov kev sib txuas ntawm trimethoprim (TMP) rau cov kab mob dihydrofolate reductase enzyme yog tsib npaug zog li ntawd rau cov tsiaj nyeg dihydrofolate reductase.Kev sib xyaw ua ke ntawm nws nrog sulfa tshuaj tuaj yeem ua rau ob qho thaiv rau cov folic acid biosynthesis metabolism ntawm cov kab mob kom muaj cov nyhuv synergistic uas yuav txhim kho cov kab mob tua kab mob ntawm sulfa tshuaj, thiab tuaj yeem tig cov nyhuv antibacterial rau cov kab mob bactericidal uas txo cov tshuaj tiv thaiv. hom kab mob.Tsis tas li ntawd, cov khoom lag luam kuj tuaj yeem txhim kho cov tshuaj tua kab mob ntawm ntau yam tshuaj tua kab mob (xws li tetracycline, gentamicin).
