Cov khoom

L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, thiab Sodium Ascorbyl Phosphate muaj nuj nqi hauv cov tshuaj pleev ib ce feem ntau ua antioxidants.Ascorbic Acid feem ntau hu ua vitamin C. Ascorbic Acid yog siv los ua antioxidant thiab pH adjuster nyob rau hauv ntau ntau hom tshuaj pleev ib ce, tshaj 3/4 ntawm cov plaub hau dyes thiab xim ntawm concentration ntawm 0.3% thiab 0.6%.Rau lwm yam kev siv, cov lus tshaj tawm cov ntsiab lus yog tsawg heev (<0.01%) lossis hauv 5% mus rau 10% ntau.Calcium Ascorbate thiab Magnesium Ascorbate tau piav qhia tias yog cov tshuaj tua kab mob antioxidant thiab cov tshuaj ua kom tawv nqaij - lwm yam siv hauv tshuaj pleev ib ce, tab sis tam sim no tsis siv.Sodium Ascorbyl Phosphate ua haujlwm ua antioxidant hauv cov khoom siv tshuaj pleev ib ce thiab siv nyob rau hauv qhov ntau ntawm 0.01% mus rau 3%.Magnesium Ascorbyl Phosphate ua haujlwm ua antioxidant hauv cov tshuaj pleev ib ce thiab tau tshaj tawm tias tau siv los ntawm 0.001% mus rau 3%.Sodium Ascorbate kuj ua haujlwm ua antioxidant hauv cov tshuaj pleev ib ce ntawm qhov ntau ntawm 0.0003% mus rau 0.3%.Cov khoom xyaw cuam tshuam (Ascorbyl Palmitate, Ascorbyl Dipalmitate, Ascorbyl Stearate, Erythorbic Acid, thiab Sodium Erythorbate) yav dhau los tau tshuaj xyuas los ntawm Cosmetic Ingredient Review (CIR) Kws Tshaj Lij Vaj Huam Sib Luag thiab pom tias "yuav muaj kev nyab xeeb rau kev siv cov khoom xyaw kom zoo nkauj hauv kev coj ua zoo tam sim no. siv."Ascorbic Acid yog feem ntau lees paub tias muaj kev nyab xeeb (GRAS) cov khoom siv los ua cov tshuaj tua kab mob hauv cov zaub mov thiab ua cov khoom noj khoom haus thiab / lossis kev noj haus.Calcium Ascorbate thiab Sodium Ascorbate tau teev tseg raws li GRAS cov khoom siv los ua cov tshuaj tua kab mob.L-Ascorbic Acid tau nkag thiab rov qab oxidized rau L-dehydroascorbic acid thiab ob qho tib si muaj nyob rau hauv qhov sib npaug hauv lub cev.Permeation tus nqi ntawm Ascorbic Acid los ntawm tag nrho thiab stripped nas daim tawv nqaij yog 3.43 +/- 0.74 microg / cm (2) / h thiab 33.2 +/- 5.2 microg / cm (2) / h.Cov kev tshawb fawb ntawm qhov ncauj thiab parenteral hauv nas, nas, luav, guinea npua, dev, thiab miv pom tau tias muaj tshuaj lom me me.Ascorbic Acid thiab Sodium Ascorbate ua raws li nitrosation inhibitor hauv ntau cov khoom noj khoom haus thiab tshuaj pleev ib ce.Tsis muaj cov tsos mob ntsig txog kev kho mob lossis tag nrho lossis cov kab mob microscopic pathological tau pom nyob rau hauv nas, nas, lossis guinea npua hauv kev tshawb fawb luv luv.Cov txiv neej guinea npua tau noj cov zaub mov tswj basal thiab muab txog li 250 mg Ascorbic Acid ntawm qhov ncauj rau 20 lub lis piam muaj cov hemoglobin zoo sib xws, cov ntshav qabzib, cov ntshav hlau, lub siab hlau, thiab siab glycogen qib piv rau kev tswj hwm.Txiv neej thiab poj niam F344/N nas thiab B6C3F(1) nas tau noj cov zaub mov uas muaj txog li 100,000 ppm Ascorbic Acid rau 13 lub lis piam nrog tshuaj lom me ntsis.Kev tshawb fawb txog kev noj zaub mov Ascorbic Acid ntev tau pom tias muaj kev phom sij ntawm cov tshuaj ntau dua 25 mg / kg lub cev qhov hnyav (bw) hauv nas thiab guinea npua.Cov pab pawg ntawm cov nas txiv neej thiab poj niam tau muab koob tshuaj txhua hnub txog li 2000 mg / kg bw Ascorbic Acid rau 2 xyoos tsis muaj macro- lossis microscopically kuaj pom muaj kab mob lom.Cov nas uas tau txais Ascorbic Acid subcutaneous thiab intravenous koob tshuaj txhua hnub (500 txog 1000 mg / kg bw) rau 7 hnub tsis muaj kev hloov pauv hauv qab los noj mov, qhov hnyav nce, thiab kev coj tus cwj pwm zoo;thiab kuaj histological ntawm ntau yam kabmob tsis pom kev hloov pauv.Ascorbic Acid yog photoprotectant thaum siv rau nas thiab npua ntawm daim tawv nqaij ua ntej raug ultraviolet (UV) hluav taws xob.Cov inhibition ntawm UV-induced suppression ntawm kev sib cuag hypersensitivity kuj tau sau tseg.Magnesium Ascorbyl Phosphate kev tswj hwm tam sim ntawd tom qab raug cov nas tsis muaj plaub hau ua rau qeeb ntawm daim tawv nqaij hlav thiab hyperplasia tshwm sim los ntawm kev raug UV hluav taws xob ntev.Cov nas thiab nas cev xeeb tub tau muab tshuaj ascorbic Acid txhua hnub hauv qhov ncauj txog li 1000 mg / kg bw yam tsis muaj kev qhia txog cov neeg laus-tshuaj lom, teratogenic, lossis fetotoxic teebmeem.Ascorbic Acid thiab Sodium Ascorbate tsis yog genotoxic nyob rau hauv ob peb kab mob thiab mammalian xeem systems, raws li cov antioxidant zog ntawm cov tshuaj.Nyob rau hauv lub xub ntiag ntawm tej yam enzyme systems los yog hlau ions, pov thawj ntawm genotoxicity tau pom.National Toxicology Program (NTP) tau ua 2-xyoo qhov ncauj carcinogenesis bioassay ntawm Ascorbic Acid (25,000 thiab 50,000 ppm) hauv F344 / N nas thiab B6C3F (1) nas.Ascorbic Acid tsis yog carcinogenic nyob rau hauv ob leeg poj niam txiv neej ntawm nas thiab nas.Inhibition ntawm carcinogenesis thiab qog loj hlob muaj feem xyuam rau Ascorbic Acid cov antioxidant zog tau raug tshaj tawm.Sodium Ascorbate tau pom los txhawb txoj kev loj hlob ntawm urinary carcinomas hauv ob-theem carcinogenesis kev tshawb fawb.Dermal daim ntawv thov ntawm Ascorbic Acid rau cov neeg mob uas muaj hluav taws xob dermatitis thiab hlawv cov neeg raug tsim txom tsis muaj kev phom sij.Ascorbic Acid yog photoprotectant hauv kev tshawb fawb tib neeg UV ntawm koob tshuaj zoo tshaj qhov tsawg kawg nkaus erythema koob (MED).Ib qho opaque cream uas muaj 5% Ascorbic Acid tsis ua rau dermal rhiab heev hauv 103 tus neeg mob.Ib yam khoom uas muaj 10% Ascorbic Acid yog nonirritant nyob rau hauv 4-hnub minicumulative patch assay ntawm tib neeg cov tawv nqaij thiab kev kho mob ntawm lub ntsej muag uas muaj 10% Ascorbic Acid tsis yog ib tug sensitizer nyob rau hauv ib tug maximization assay ntawm 26 tib neeg.Vim hais tias ntawm cov qauv thiab kev ua haujlwm zoo sib xws ntawm cov khoom xyaw no, Vaj Huam Sib Luag ntseeg tias cov ntaub ntawv ntawm ib qho khoom muaj tuaj yeem raug ntxiv rau tag nrho lawv.Cov Kws Tshaj Lij Tshaj Lij tau lees paub qhov kev tshawb pom tias Ascorbic Acid yog genotoxic nyob rau hauv ob peb qhov kev ntsuam xyuas no vim muaj lwm yam tshuaj, xws li, hlau, lossis qee lub tshuab enzyme, uas tau hloov pauv Ascorbic Acid cov tshuaj tiv thaiv antioxidant rau cov pro-oxidant.Thaum Ascorbic Acid ua raws li cov tshuaj tiv thaiv antioxidant, Vaj Huam Sib Luag xaus lus tias Ascorbic Acid tsis yog genotoxic.Kev txhawb nqa qhov kev pom no yog cov kev tshawb fawb carcinogenicity ua los ntawm NTP, uas tsis muaj pov thawj ntawm carcinogenicity.Ascorbic Acid tau pom tias muaj txiaj ntsig zoo inhibit nitrosamine tawm los hauv ntau lub tshuab kuaj.Lub Vaj Huam Sib Luag tau tshuaj xyuas cov kev tshawb fawb uas Sodium Ascorbate ua raws li cov qog nqaij hlav hauv cov tsiaj.Cov txiaj ntsig no tau raug suav hais tias muaj feem cuam tshuam rau qhov concentration ntawm sodium ions thiab pH ntawm cov zis hauv cov tsiaj sim.Cov teebmeem zoo sib xws tau pom nrog sodium bicarbonate.Vim tias muaj kev txhawj xeeb tias qee cov hlau ions tuaj yeem ua ke nrog cov khoom xyaw no los tsim cov kev ua haujlwm oxidant, Lub Vaj Huam Sib Luag tau ceeb toom cov neeg tsim khoom kom paub tseeb tias cov khoom xyaw no ua cov tshuaj antioxidants hauv cov tshuaj pleev ib ce.Lub Vaj Huam Sib Luag tau ntseeg tias qhov kev sim tshuaj uas Ascorbic Acid tau siv rau ntawm daim tawv nqaij puas yam tsis muaj kev phom sij thiab qhov rov ua dua qhov ntsuas patch (RIPT) siv 5% Ascorbic Acid nrog cov txiaj ntsig tsis zoo txhawb kev tshawb pom tias pawg ntawm cov khoom xyaw no tsis nthuav tawm. txaus ntshai ntawm daim tawv nqaij rhiab heev.Cov ntaub ntawv no ua ke nrog qhov tsis muaj ntawv ceeb toom hauv cov ntaub ntawv kho mob ntawm Ascorbic Acid rhiab heev txhawb kev nyab xeeb ntawm cov khoom xyaw no.