Cov khoom

Sitagliptin yog ib hom tshuaj uas muaj nyob rau hauv ib chav kawm ntawm cov tshuaj hu ua dipeptidyl peptidase-4 (DPP-4) inhibitors.Nws yog feem ntau siv hauv kev tswj hwm hom 2 mob ntshav qab zib mellitus.Mob ntshav qab zib tshwm sim thaum lub cev tsis tuaj yeem tswj cov ntshav qab zib kom zoo, ua rau muaj cov piam thaj hauv cov ntshav siab.Sitagliptin ua haujlwm los ntawm inhibiting DPP-4 enzyme, uas yog lub luag haujlwm rau kev rhuav tshem cov tshuaj hormones incretin.Cov tshuaj hormones no nce insulin secretion thiab txo qis glucagon ntau lawm, thaum kawg ua rau cov ntshav qab zib ntau dua.Los ntawm inhibiting DPP-4 enzyme, sitagliptin tso cai rau cov tshuaj hormones incretin kom nyob twj ywm rau lub sijhawm ntev, yog li txhim kho cov ntshav qab zib.Cov thawj coj ntawm sitagliptin yog qhov ncauj, thiab nws tuaj yeem noj nrog lossis tsis muaj zaub mov.Qhov ntau npaum li cas los ntawm tus kws kho mob yuav yog nyob ntawm tus neeg mob yam xwm txheej, xws li mob ntshav qab zib thiab lwm yam tshuaj siv.Nws yog ib qho tseem ceeb uas yuav tsum tau ua raws li cov lus qhia noj tshuaj kom zoo thiab tsis txhob kho qhov ntau npaum li cas yam tsis tau sab laj nrog kws kho mob.Sitagliptin feem ntau yog siv los ua ib qho ntxiv rau kev noj haus thiab kev tawm dag zog hauv kev tswj hwm hom 2 mob ntshav qab zib mellitus.Nws yog feem ntau sau nrog kev hloov pauv hauv kev ua neej thiab lwm yam tshuaj tiv thaiv kab mob, xws li metformin.Los ntawm kev sib xyaw cov txheej txheem sib txawv, xws li sitagliptin's DPP-4 inhibition thiab metformin txhim kho cov tshuaj insulin, kev tswj glycemic zoo tuaj yeem ua tiav.Qhov kev ua tau zoo ntawm sitagliptin hauv kev tswj cov ntshav qab zib tau pom hauv ntau qhov kev sim tshuaj.Cov kev tshawb fawb tau pom tias nws tuaj yeem txo qis kev yoo mov thiab postprandial (tom qab noj mov) cov piam thaj, txo glycated hemoglobin (HbA1c) ntau ntau, thiab txhim kho tag nrho glycemic tswj.Sitagliptin feem ntau tau txais txiaj ntsig zoo, nrog cov kev mob tshwm sim feem ntau yog mob me, xws li raws li mob taub hau, kab mob ua pa sab sauv, thiab mob plab hnyuv xws li xeev siab lossis raws plab.Raws li nrog rau txhua yam tshuaj, kev tsis haum tshuaj loj thiab tsis tshua muaj tshwm sim tab sis muaj kev phiv loj tuaj yeem tshwm sim, yog li nws yog ib qho tseem ceeb uas yuav tsum tau tshaj tawm cov tsos mob txawv txawv lossis mob hnyav rau tus kws kho mob tam sim ntawd. .Raws li DPP-4 inhibitor, nws pab txhim kho glycemic tswj los ntawm kev ua haujlwm ntev ntawm cov tshuaj hormones incretin.Thaum siv nrog rau kev hloov pauv kev ua neej thiab lwm yam tshuaj tiv thaiv kab mob, sitagliptin tuaj yeem yog ib qho cuab yeej zoo hauv kev tswj cov ntshav qab zib thiab tswj ntshav qab zib hom 2.Kev soj ntsuam ze thiab kev sab laj nrog tus kws kho mob yog qhov tseem ceeb rau kev ua tau zoo.