S-Butyrylthiocholine iodide CAS: 1866-16-6 98% Dawb crystalline khoom
| Catalog Number | xwm 90143 |
| Khoom npe | S-Butyrylthiocholine iodide |
| CAS | 1866-16-6 |
| Molecular Formula | C9H20 NOS |
| Molecular Luj | 317.23 Nws |
| Cov ntaub ntawv khaws cia | -15 rau -20 ° C |
| Harmonized tariff Code | 29 3098 ib |
Khoom Specification
| Qhov tshwm sim | Dawb crystalline khoom |
| Assay | > 98% |
| Melting Point | 173-178 Deg C |
| Solubility | Dissolves nyob rau hauv dej kom muab ib tug ntshiab colorless tov |
| Tsis-Volatile Matter | <1% |
Multitarget compounds tau nce zuj zus mus rau kev kho mob ntawm cov kab mob nyuaj.Ntawm no, peb piav qhia txog kev tsim thiab kev sib txuas ntawm cov chav kawm tshiab ntawm shogaol-huprine hybrids, tau qhia tias ntaus ntau lub hom phiaj tseem ceeb koom nrog Alzheimer's disease.Cov hybrids tau raug sim hauv vitro rau lawv cov kev ua haujlwm inhibitory tiv thaiv tib neeg acetylcholinesterase thiab butyrylcholinesterase thiab kev ua haujlwm antioxidant (ABTS.+, DPPH thiab Folin-Ciocalteu assays), thiab hauv cov hlwb Escherichia coli rau lawv cov Aβ42 thiab tau los tiv thaiv kev sib sau ua ke.Tsis tas li ntawd, lawv lub hlwb nkag mus tau raug soj ntsuam (PAMPA-BBB assay).Txawm hais tias cov hybrids tsis muaj zog AChE inhibitors lossis cov tshuaj tua kab mob antioxidant li niam txiv huprine Y thiab [4]-shogaol, feem, lawv tseem muaj cov tshuaj tiv thaiv anticholinesterase thiab cov tshuaj tiv thaiv antioxidant thiab muaj zog ntau dua Aβ42 thiab tau los tiv thaiv kev sib sau ua ke ntau dua li ntawm niam txiv sib xyaws.Zuag qhia tag nrho, shogaol-huprine hybrids tshwm sim raws li nthuav lub hlwb permeable multitarget anti-Alzheimer ua.
Extracts ntawm txawv polarity tau los ntawm ntau yam nroj tsuag (hauv paus, nplooj, paj thiab txiv hmab txiv ntoo) ntawm Seseli rigidum tau kawm los ntawm txawv antioxidant assays: DPPH thiab ABTS radical scavenging kev ua, los ntawm tag nrho cov txo hwj chim txoj kev raws li tau zoo raws li tag nrho cov ntsiab lus ntawm flavonoids thiab polyphenols. .Cov roj tseem ceeb ntawm txhua qhov chaw cog tau pom cov yam ntxwv tsis muaj zog antioxidant.Cov tshuaj inhibitory concentration ntau ntawm cov tshuaj tua kab mob, tiv thaiv kab mob Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, thiab fungi Candida albicans thiab Aspergillus niger yog 0.01-1.50 mg / mL thiab ntawm microbicidal-3.0.02.Hauv kev sib cuam tshuam nrog cholinesterase, tag nrho cov roj tseem ceeb tau ua pov thawj zoo li inhibitors.Qhov feem pua siab tshaj plaws ntawm inhibition piv rau tib neeg thiab nees cholinesterase tau pom los ntawm cov hauv paus tseem ceeb roj (38.20% thiab 48.30%, feem) ntawm cov roj, thiab hauv paus hexane extract (40.56% thiab 50.65% feem).Cov roj tseem ceeb thiab cov khoom tsis muaj zog ntawm tag nrho cov nroj tsuag tau txheeb xyuas los ntawm GC, GC-MS thiab headspace / GC-MS.Kev txheeb cais ntawm pawg ntawm cov txiaj ntsig tau pom tias cov hauv paus tseem ceeb roj muaj pes tsawg leeg sib txawv ntawm cov roj tseem ceeb ntawm lwm qhov ntawm cov nroj tsuag.Noj mus rau hauv tus account tag nrho cov kev kawm ua ub no, lub hauv paus hexane extract qhia qhov zoo tshaj plaws tag nrho cov khoom.Los ntawm txoj kev ua haujlwm siab ua kua chromatography ua ke rau kev daws teeb meem loj spectrometry, 30 feem ntau cov khoom siv tau pom nyob rau hauv cov khoom sib txawv ntawm cov polarity.Lub xub ntiag ntawm cov pov thawj uas tau txheeb xyuas tau txuas mus rau kev soj ntsuam kev ua haujlwm lom neeg tshwj xeeb, yog li tsim cov tebchaw uas muaj feem cuam tshuam rau txhua qhov kev ua yeeb yam.
