Cov khoom

(S)-(2-Chloro-5-iodophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)methanone, tseem hu ua CF3-112, yog cov tshuaj sib xyaw nrog ntau daim ntawv thov tseem ceeb hauv thaj chaw tshuaj chemistry thiab tshuaj Kev loj hlob.Ib qho kev siv loj ntawm CF3-112 yog raws li kinase inhibitor.Kinases yog cov enzymes uas tswj hwm ntau cov txheej txheem ntawm tes hauv lub cev, suav nrog kev loj hlob ntawm tes, kev faib tawm, thiab kev sib txuas lus.Dysregulation ntawm kinases feem ntau cuam tshuam nrog cov kab mob xws li mob qog noj ntshav thiab kab mob autoimmune.CF3-112 tau pom tias muaj peev xwm tiv thaiv kev ua haujlwm tiv thaiv qee yam kinases, ua rau nws yog ib tus neeg sib tw zoo rau kev txhim kho cov hom phiaj kho mob.Tshwj xeeb, CF3-112 tau pom tias muaj kev tiv thaiv kev tiv thaiv Aurora kinases, uas ua lub luag haujlwm tseem ceeb hauv kev faib cell thiab feem ntau overexpressed nyob rau hauv cov qog nqaij hlav cancer.Los ntawm kev xaiv lub hom phiaj thiab inhibiting cov kinases no, CF3-112 tuaj yeem pab tiv thaiv kev loj hlob sai ntawm cov qog nqaij hlav cancer thiab muaj peev xwm muab cov txiaj ntsig kho mob. Tsis tas li ntawd, CF3-112 tau ua haujlwm tawm tsam lwm cov kinases xws li FLT3 thiab JAK2, uas cuam tshuam hauv hematological. malignancies xws li mob myeloid leukemia (AML) thiab myeloproliferative neoplasms.Inhibiting cov kinases nrog CF3-112 muaj peev xwm cuam tshuam cov kev taw qhia txoj hauv kev uas tsav kev loj hlob thiab ciaj sia ntawm cov qog nqaij hlav cancer, muab cov kev muaj peev xwm tshiab rau kev kho mob ntawm cov kab mob no. Ntxiv rau nws cov kinase inhibitory kev ua, CF3-112 kuj tseem muaj cov tshuaj tiv thaiv. - inflammatory teebmeem.Inflammation yog ib tug complex biological teb uas plays lub luag hauj lwm nyob rau hauv ntau yam kab mob, nrog rau cov kab mob autoimmune thiab mob ntev.CF3-112 tau pom cov lus cog tseg tias yog ib qho inhibitor ntawm qee txoj hauv kev inflammatory, muaj peev xwm muab txoj hauv kev kho mob rau kev tswj cov mob no.Thaum CF3-112 tuav lub peev xwm zoo, nws tsim nyog sau cia tias kev tshawb fawb ntxiv thiab kev txhim kho yog xav tau kom nkag siab tag nrho nws cov txiaj ntsig, kev nyab xeeb. profile, thiab kev siv zoo tshaj plaws.Raws li nrog txhua qhov sib xyaw, kev sim nruj thiab kev tshawb fawb ua ntej yuav tsum tau ua ua ntej nws tuaj yeem ua tiav rau tib neeg kev sim tshuaj.Nws cov kinase inhibitory kev ua haujlwm, tshwj xeeb tshaj yog tawm tsam Aurora kinases, FLT3, thiab JAK2, tso nws ua tus neeg sib tw muaj peev xwm rau kev txhim kho cov phiaj xwm kho mob qog noj ntshav thiab hematological malignancies.Nws cov khoom tiv thaiv kab mob kuj tseem qhia txog cov kev siv hauv kev tswj cov kab mob autoimmune thiab mob ntev.Txawm li cas los xij, kev tshawb fawb ntxiv yog tsim nyog los qhib nws lub peev xwm kho mob tag nrho thiab ntsuas nws txoj kev nyab xeeb thiab kev ua tau zoo.