Cov khoom

Rosuvastatin Intermediates ZD9, tseem hu ua Z-4-(4-Fluorophenyl)-6-Isopropyl-2-[(N-Methyl-N-Methylsulfonyl)Amino] Pyrimidin-5-Yl, yog ib qho tshuaj lom neeg ua haujlwm tseem ceeb. Qhov nruab nrab hauv kev sib xyaw ntawm cov tshuaj txo cov roj cholesterol Rosuvastatin.Qhov nruab nrab no ua lub luag haujlwm tseem ceeb hauv kev tsim cov rosuvastatin, uas belongs rau cov chav kawm ntawm cov tshuaj hu ua statins.ZD9 ua raws li cov khoom sib xyaw ua ntej hauv kev sib txuas ntawm ntau theem ntawm Rosuvastatin.Thaum lub sij hawm tsim cov txheej txheem, ZD9 dhau ntau yam tshuaj hloov pauv mus rau qhov kawg ntawm cov khoom kawg, Rosuvastatin.Qhov kev sib txuas no cuam tshuam nrog kev sib txuas ntawm cov pab pawg ua haujlwm ntxiv mus rau ZD9 molecule, uas ua rau tsim cov tshuaj nquag, Rosuvastatin.Rosuvastatin yog dav siv rau kev kho mob hypercholesterolemia, ib qho mob uas muaj cov roj cholesterol ntau hauv cov ntshav.Nws ua haujlwm los ntawm inhibiting enzyme HMG-CoA reductase, uas ua lub luag haujlwm tseem ceeb hauv kev tsim cov roj cholesterol hauv lub cev.Los ntawm kev txo qis cov roj cholesterol, Rosuvastatin pab txo qis cov roj cholesterol tag nrho, suav nrog cov roj lipoprotein tsawg (LDL) cov roj cholesterol, feem ntau hu ua "phem" cov roj cholesterol.Raws li qhov sib xyaw nruab nrab, ZD9 xyuas kom meej tias cov synthesis ntawm Rosuvastatin nce hauv kev tswj hwm. thiab kev ua tau zoo.Nws ua raws li lub tsev thaiv uas ua rau muaj kev cuam tshuam ntawm cov tshuaj lom neeg, ua rau tsim cov kev sib txuas tshwj xeeb thiab cov pab pawg ua haujlwm tsim nyog rau Rosuvastatin's pharmacological kev ua haujlwm.Lub synthesis ntawm Rosuvastatin yog cov txheej txheem nyuaj, thiab txhua qhov nruab nrab, suav nrog ZD9, yog qhov tseem ceeb hauv kev ua kom ntseeg tau. qhov tsim nyog ntawm cov khoom kawg.Yog tsis muaj ZD9, kev sib txuas ntawm Rosuvastatin yuav tsis tuaj yeem ua tau, cuam tshuam kev tsim cov tshuaj txo cov roj cholesterol hauv cov ntsiab lus.Nws ua raws li lub tsev thaiv uas dhau los ntawm cov tshuaj hloov pauv mus rau qhov kawg tawm los ntawm cov khoom siv tshuaj.Los ntawm kev ua lub luag haujlwm tseem ceeb hauv cov txheej txheem tsim khoom, ZD9 pab txhawb kom muaj cov tshuaj tseem ceeb rau kev kho cov roj cholesterol siab hauv cov neeg mob.