Cov khoom

Qhov inhibition ntawm β-carbonic anhydrases (CAs, EC 4.2.1.1) los ntawm cov kab mob fungi Cryptococcus neoformans (Can2) thiab Candida albicans (Nce103) nrog ib tug series ntawm 25 ceg aliphatic thiab aromatic carboxylates tau raug tshawb xyuas.Tib neeg isoforms hCA I thiab II kuj tau suav nrog hauv kev tshawb fawb rau kev sib piv.Aliphatic carboxylates feem ntau yog millimolar hCA I thiab II inhibitors thiab qis micromolar / submicromolar β-CA inhibitors.Aromatic carboxylates yog micromolar inhibitors ntawm plaub enzymes tab sis qee qhov ntawm lawv tau pom cov kev ua haujlwm tsawg nanomolar tiv thaiv cov kab mob fungal.4-Hydroxy- thiab 4-methoxy-benzoate inhibited Can2 nrog K(I)s ntawm 9.5-9.9 nM.Cov methyl esters, hydroxamates, hydrazides thiab carboxamides ntawm qee yam ntawm cov derivatives no kuj zoo inhibitors ntawm α- thiab β-CAs tau tshawb xyuas ntawm no.

Parabens yog ib qho ntawm feem ntau siv preservatives los inhibit microbial kev loj hlob thiab ncua lub txee lub neej ntawm ntau yam khoom siv.Lub hom phiaj ntawm txoj kev tshawb fawb tam sim no yog kom nkag siab txog cov metabolism ntawm parabens hauv cov qog nqaij hlav cancer mis (MCF7) txij li lawv tau pom cov kev ua estrogenic rau cov hlwb thiab tau kuaj pom hauv cov ntaub so ntswg cancer mis.Cov tshuaj toxicity ntawm parabens rau MCF7 hlwb tau txiav txim siab siv MTT kev soj ntsuam.Hydrolysis ntawm methyl-, butyl thiab benzyl-paraben rau p-hydroxybenzoic acid tau soj ntsuam hauv kab lis kev cai MCF7 hlwb thiab hauv cellular homogenates.Glucuronidation thiab sulfoconjugation tau kawm hauv MCF7 homogenates, thiab parabens raug tshuaj xyuas los ntawm HPLC.Methyl-paraben tau pom tias muaj tshuaj lom tsawg dua li butyl thiab benzyl-paraben.Parabens tau ruaj khov hauv MCF7 homogenates thaum p-nitrophenyl acetate, ib hom substrate, underwent hydrolysis.MCF7 cell homogenates tsis qhia txog glucuronidation thiab sulfoconjugation cov dej num rau parabens.Kev ruaj ntseg siab dua ntawm parabens tuaj yeem piav qhia lawv cov khoom sib txuam hauv cov ntaub so ntswg cancer mis.