Nicotinamide Riboside CAS 1341-23-7
| Catalog Number | xwm 91951 |
| Khoom npe | Nicotinamide Riboside |
| CAS | 1341-23-7 : kuv |
| Molecular Formula | C11H15N2O5+ |
| Molecular Luj | 255.25 Nws |
| Cov ntaub ntawv khaws cia | Ambient |
| Harmonized tariff Code | 2933199090 ib |
Khoom Specification
| Qhov tshwm sim | Dawb hmoov |
| Assay | 99% min |
Nicotinamide Riboside tuaj yeem siv rau hauv kev tshawb fawb lom neeg ntawm cov noob circadian reprogramming transcriptome hauv daim siab txheeb xyuas cov txheej txheem metabolic ntawm kev laus hauv nas.Nws kuj nce NAD + hauv cerebral cortex thiab txo qhov kev xav tsis zoo nyob rau hauv tus qauv transgenic nas ntawm Alzheimer's kab mob.
Nicotinamide adenine dinucleotide (NAD +) yog ib qho tseem ceeb coenzyme uas, thaum txo qis rau NADH, ua haujlwm txo tus neeg sawv cev pub dawb electrons rau oxidative phosphorylation thiab ATP synthesis hauv mitochondria.NAD + yog ib qho tseem ceeb cofactor rau cov enzymes xws li sirtuins, ADP-ribosyltransferases (ARTs), thiab Poly [ADP- ribose] polymerases (PARPs) thiab tau noj tas li los ntawm cov enzymes no.NAD + / NADH piv yog qhov tseem ceeb ntawm lub xeev redox ntawm tes.(Vaj tswv 2015).Los ntawm qee qhov suav, NAD lossis lwm yam NADP koom nrog hauv ib lub hlis twg ntawm txhua qhov kev tshwm sim ntawm tes (Opitz Heiland 2015).Muaj cais cais ntawm NAD + hauv cov nucleus, mitochondria, thiab cytoplasm (Verdin 2015).
Nicotinamide riboside (NR) tuaj yeem hloov mus rau hauv NAD + los ntawm cov kauj ruam nruab nrab uas nws hloov mus rau hauv nicotinamide mononucleotide (NMN) los ntawm NR kinase (Nrk) thiab tom qab ntawd mus rau NAD + los ntawm NMNATs.NR yog ib txwm pom muaj nyob rau hauv qee yam khoom noj tab sis muaj tsawg heev (xws li tsawg micromolar ntau).Keeb kwm, NR yog ib qho nyuaj kom tau txais cov nyiaj purified loj, tab sis ua tsaug rau kev nce qib hauv cov txheej txheem synthesis (Yang 2007), txij li lub Rau Hli 2013, nws raug muag raws li kev noj haus ntxiv.
