Cov khoom

N-(5-bromo-[1,3]thiazolo[4,5-b]pyridin-2-yl)benzamide yog ib qho tshuaj sib xyaw nrog cov kev siv hauv kev tshawb fawb tshuaj, tshwj xeeb hauv kev tsim cov tshuaj tshiab.Nws cov qauv molecular tshwj xeeb uas muaj cov thiazolo[4,5-b]pyridine thiab benzamide moieties muaj cib fim rau ntau yam kev siv tshuaj.Ib qho kev siv ntawm N-(5-bromo-[1,3]thiazolo[4,5-b ]pyridin-2-yl) benzamide yog cov tshuaj pharmacophore, ib qho tseem ceeb ntawm cov qauv uas cuam tshuam nrog cov hom phiaj lom neeg hauv lub cev.Lub xub ntiag ntawm thiazolo [4,5-b] pyridine nplhaib tso cai rau cov khoom sib xyaw tsim los ua lub peev xwm ligand thiab khi rau cov hom phiaj tshwj xeeb, xws li receptors lossis enzymes, koom nrog ntau yam kab mob.Los ntawm kev hloov pauv cov neeg hloov pauv ntawm thiazolo [4,5-b] pyridine nplhaib lossis pawg benzamide, cov kws tshawb fawb tuaj yeem kho qhov sib xyaw ua ke rau cov phiaj xwm tshwj xeeb lossis kab mob.Cov tshuaj no tuaj yeem ua lub luag haujlwm pib rau kev sib txuas thiab kev ua kom zoo ntawm cov hlau lead hauv cov kev tshawb nrhiav tshuaj.Ntxiv mus, N-(5-bromo-[1,3]thiazolo[4,5-b]pyridin-2-yl)benzamide tuaj yeem siv rau hauv kev sib raug zoo-kev sib raug zoo (SAR).Los ntawm synthesizing derivatives thiab analogs ntawm cov compound no, cov kws tshawb fawb tuaj yeem soj ntsuam seb qhov kev hloov pauv txawv li cas cuam tshuam rau nws txoj haujlwm lom neeg thiab muaj zog.Cov ntaub ntawv no yog qhov tseem ceeb hauv kev tsim qauv ntawm cov neeg sib tw tshuaj tshiab nrog kev txhim kho kev ua tau zoo thiab txo cov kev mob tshwm sim. Ntxiv rau kev tshawb nrhiav tshuaj, N-(5-bromo-[1,3]thiazolo[4,5-b]pyridin-2- yl) benzamide tuaj yeem nrhiav tau daim ntawv thov hauv tshuaj lom neeg lom neeg thiab kev tshawb fawb txog hom phiaj.Nws tuaj yeem siv los ua cov cuab yeej sib xyaw hauv cov tshuaj lom neeg lom neeg los qhia txog kev ua haujlwm ntawm cov hom phiaj tshwj xeeb thiab txoj hauv kev hauv cov txheej txheem ntawm tes.Los ntawm kev kawm txog qhov cuam tshuam ntawm cov tshuaj no ntawm cov xov tooj ntawm tes, cov kws tshawb fawb tuaj yeem tau txais kev nkag siab zoo rau hauv cov txheej txheem ntawm cov kab mob thiab muaj peev xwm txheeb xyuas cov hom phiaj kho mob tshiab. Tsis tas li ntawd, N-(5-bromo-[1,3]thiazolo[4,5-b ]pyridin-2-yl) benzamide tuaj yeem ua haujlwm hauv kev tshawb fawb tshuaj chemistry rau kev txhim kho cov tshuaj tiv thaiv kab mob.Thiazolo [4,5-b] pyridine derivatives tau pom cov lus cog tseg hauv inhibiting ntau txoj hauv kev mob qog noj ntshav, xws li cov protein kinases koom nrog hauv kev loj hlob ntawm tes thiab kev ciaj sia.Los ntawm kev sib koom ua ke ntawm bromine hloov pauv thiab pab pawg benzamide, qhov sib xyaw ua ke muaj zog thiab kev xaiv raws li tus neeg sawv cev tiv thaiv kab mob tuaj yeem tshawb nrhiav ntxiv thiab ua kom zoo dua qub. -2-yl) benzamide yog ib qho tseem ceeb sib xyaw nrog cov ntawv thov hauv kev tshawb fawb tshuaj.Nws cov qauv tshwj xeeb muab lub sijhawm rau kev tsim thiab kev sib txuas ntawm cov hlau lead, kev tshawb fawb SAR, kev txheeb xyuas lub hom phiaj, thiab kev txhim kho cov tshuaj tiv thaiv kab mob.Qhov sib xyaw ua ke muaj ntau yam thiab muaj peev xwm hauv kev tshawb nrhiav tshuaj qhia txog nws qhov tseem ceeb hauv kev nce qib ntawm cov tshuaj chemistry thiab nws cov peev xwm pab rau kev txhim kho cov kev kho tshiab.