N-(2-Acetamide) iminodiacetic acid Cas: 26239-55-4 99% Dawb hmoov
| Catalog Number | xwm 90194 |
| Khoom npe | ADA (N-(-2-Acetamido) iminodiacetic acid) |
| CAS | 26239-55-4 |
| Molecular Formula | C6H10N2O5 |
| Molecular Luj | 190.15 Nws |
| Cov ntaub ntawv khaws cia | Ambient |
| Harmonized tariff Code | 29241900 ib |
Khoom Specification
| Fe | <5 ppm |
| Pb | <5 ppm |
| Poob rau ziab | <0.5% |
| Sulfated tshauv | <0.1% |
| Qhov tshwm sim | Dawb hmoov |
| Lwm cov kuab tshuaj | Tsis muaj |
| Lub Sij Hawm Lub Sij Hawm (9g hauv 91ml 1M NaOH, Sib Nqus Stirring) | <1 min |
| A300 (9% hauv 1 M NaOH) | <0.08% |
| Number of endpoints Pom nyob rau hauv titration nkhaus | Ob tug xwb |
| pH Range uas txhais qhov Titration Thib Ob Qhov Kawg | 9.1-10.1 Nws |
| Solubility (9% hauv 1M NaOH) | Ntshiab thiab tsis muaj xim |
| Hnub tsim khoom | |
| KF dej | <1% |
| Assay (Titration) ntawm lub hauv paus qhuav | > 99.0% |
| Infrared | Ua raws |
Cov nucleoside adenosine ua rau lub paj hlwb thiab cov hlab plawv ntawm A2A receptor (A2AR).Hauv kev teb rau qib oxygen hauv cov ntaub so ntswg, adenosine plasma concentration yog tswj hwm tshwj xeeb los ntawm nws cov synthesis los ntawm CD73 thiab los ntawm nws cov degradation los ntawm adenosine deaminase (ADA).Lub cell-nto endopeptidase CD26 tswj cov concentration ntawm vasoactive thiab antioxidant peptides thiab yog li tswj cov pa oxygen rau cov ntaub so ntswg thiab oxidative kev nyuaj siab teb.Txawm hais tias overexpression ntawm adenosine, CD73, ADA, A2AR, thiab CD26 nyob rau hauv cov lus teb rau hypoxia yog cov ntaub ntawv zoo, cov teebmeem ntawm hyperoxic thiab hyperbaric mob ntawm cov ntsiab lus tsim nyog xav txog ntxiv.nas thiab murine Chem-3 cell kab uas qhia A2AR raug 0.21 bar O2, 0.79 bar N2 (terrestrial tej yam kev mob; normoxia);1 bar O2 (hyperoxia);2 bar O2 (hyperbaric hyperoxia);0.21 bar O2, 1.79 bar N2 (hyperbaria).Adenosine plasma concentration, CD73, ADA, A2AR qhia, thiab CD26 kev ua haujlwm tau hais hauv vivo, thiab cAMP ntau lawm tau hais hauv cellulo.Rau hauv vivo tej yam kev mob, 1) hyperoxia txo qis adenosine plasma qib thiab T cell nto CD26 kev ua, thaum nws nce CD73 qhia thiab ADA qib;2) hyperbaric hyperoxia tended ua kom nrov nrov;thiab 3) hyperbaria ib leeg tsis muaj kev cuam tshuam tseem ceeb ntawm cov kev txwv no.Hauv lub hlwb thiab hauv cellulo, 1) hyperoxia txo A2AR qhia;2) hyperbaric hyperoxia amplified tus qauv;thiab 3) hyperbaria ib leeg tau nthuav tawm cov txiaj ntsig zoo tshaj plaws.Peb pom cov qauv zoo sib xws hais txog ob qho tib si A2AR mRNA synthesis hauv lub hlwb thiab cAMP ntau lawm hauv Chem-3 hlwb.Yog li cov pa oxygen siab tau ua rau txo qis txoj hauv kev adenosinergic thiab CD26 kev ua haujlwm.Hyperbaria ib leeg cuam tshuam tsuas yog A2AR qhia thiab cAMP ntau lawm.Peb sib tham txog yuav ua li cas cov txheej txheem no tshwm sim los ntawm hyperoxygenation tuaj yeem txwv, los ntawm vasoconstriction, cov pa oxygen rau cov ntaub so ntswg thiab tsim cov hom pa oxygen reactive.
