Cov khoom

Methyl 4-(4-Fluorophenyl)-6-Isopropyl-2-[(N-methyl-N-methylsulfonyl)amino] pyrimidine-5-carboxylate, tseem hu ua Z6, yog ib qho chaw nrog ntau yam kev siv hauv kev lag luam kws tshuaj .Lub xub ntiag ntawm fluoro-hloov phenyl pawg txuas nrog lub nplhaib pyrimidine qhia tias Z6 tuaj yeem cuam tshuam nrog lub hom phiaj lom neeg, ua rau nws muaj kev cia siab rau kev tshawb nrhiav tshuaj.Kev koom ua ke ntawm pawg isopropyl txhim kho qhov sib xyaw ua ke ntawm hydrophobicity, muaj peev xwm txhim kho nws lub peev xwm nkag mus rau hauv cov ntaub so ntswg lom thiab ncav cuag lub hom phiaj ntawm qhov chaw.Lwm qhov tseem ceeb ntawm Z6 yog qhov muaj N-methyl-N-methylsulfonyl amino pawg.Cov pab pawg ua haujlwm no tau cuam tshuam nrog kev txhim kho cov txheej txheem metabolic ruaj khov thiab txo qhov cuam tshuam tsis zoo.Nws kuj tseem tuaj yeem pab txhawb rau qhov sib xyaw ua ke hauv cov polar ib puag ncig.Cov khoom no tuaj yeem muaj txiaj ntsig zoo hauv kev tsim cov tshuaj bioactive.Qhov muaj cov methyl ester pawg hauv Z6 muab kev ntsuas kev ruaj ntseg thiab yooj yim ntawm kev tuav.Tsis tas li ntawd, pawg carboxylate ntawm 5-txoj hauj lwm ntawm lub nplhaib pyrimidine tuaj yeem ua qhov chaw muaj peev xwm rau kev hloov kho tshuaj, tso cai rau kev tshawb fawb txog kev sib raug zoo-kev sib raug zoo thiab kev ua kom zoo ntawm cov tshuaj pharmacological.Z6 cov qauv nta qhia tias nws yuav muaj peev xwm siv tau raws li kev siv tshuaj. Cov khoom xyaw (API) rau kev kho mob ntawm ntau yam kab mob.Nws tuaj yeem tshawb nrhiav rau nws lub peev xwm ua tus neeg sawv cev tiv thaiv kab mob, tshuaj tiv thaiv kab mob, lossis hauv kev kho mob qog noj ntshav.Kev sib xyaw ua ke tshwj xeeb ntawm cov pab pawg ua haujlwm tuaj yeem muab sijhawm rau kev xaiv lom neeg sib cuam tshuam, ua rau nws yog ib tus neeg sib tw txaus nyiam rau kev siv tshuaj yeeb yaj kiab. Ntxiv mus, Z6 cov txheej txheem nyuaj thiab ntau haiv neeg ua rau nws yog qhov pib nthuav qhia rau kev tsim cov tsev qiv ntawv me me lossis cov tshuaj scaffolds.Nws tuaj yeem ua lub tsev thaiv rau kev sib txuas ntawm cov qauv sib txawv ntawm cov khoom sib txawv, ua rau kev tshawb nrhiav ntawm cov qauv-kev sib raug zoo thiab kev txheeb xyuas cov khoom siv lead ua rau kev ua kom zoo dua ntxiv.Nyob rau hauv xaus, Z6, nrog nws cov yam ntxwv txawv thiab cov pab pawg ua haujlwm, tuav cov lus cog tseg rau ntau yam kev siv tshuaj.Nws muaj peev xwm ua API, ua ke nrog ntau yam kev hloov kho thiab ua kom zoo, ua rau nws muaj txiaj ntsig zoo rau kev tshawb nrhiav tshuaj thiab kev txhim kho.Kev tshawb fawb ntxiv thiab kev tshawb fawb yog tsim nyog los tshawb nrhiav thiab siv nws cov peev xwm kho mob.