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Liraglutide CAS 204656-20-2

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Catalog Number: xwm 92579
Cas: 204656-20-2
Molecular Formula: C172H265N43O51
Molecular Luj: 3751.20 Nws
Muaj: Hauv Tshuag
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Prepack:  
Ntim Pob: Thov Quote

 


Product Detail

Khoom cim npe

Catalog Number xwm 92579
Khoom npe Liraglutide
CAS 204656-20-2
Molecular Formula C172H265N43O51
Molecular Luj 3751.20 Nws
Cov ntaub ntawv khaws cia Ambient

Khoom Specification

Qhov tshwm sim Dawb hmoov
Assay 99% min

 

Txoj hauv kev los kho T2DM, tus kab mob tshwm sim los ntawm ob qhov tsis xws luag ntawm islet cell ua haujlwm tsis zoo thiab insulin tsis kam, suav nrog cov neeg ua haujlwm uas ua rau kom muaj cov tshuaj insulin los ntawm cov txiav (secretagogues), cov neeg ua haujlwm uas ua rau muaj kev nkag siab ntawm lub hom phiaj lub cev rau insulin (sensitizers), thiab Cov neeg ua haujlwm uas txo qis cov piam thaj nqus los ntawm lub plab zom mov.Liraglutide, GLP-1 receptor agonist mus txog kev ua lag luam, muaj 97% homology rau GLP-1 nrog tsuas yog ob qho kev hloov pauv amino acid thiab qhov sib ntxiv ntawm fatty acid sab saw.Tshwj xeeb, lysine nyob rau hauv txoj hauj lwm 34 tau hloov nrog ib qho arginine, thiab cov lysine nyob rau hauv txoj hauj lwm 26 tau hloov kho nrog ib tug C16 acyl saw ntawm ib tug glutamoyl spacer.Liraglutide muab nws qhov kev tiv thaiv rau DPP-4 degradation los ntawm nws txoj kev xav los tsim micelles thiab khi rau albumin.Tsis zoo li nws thawj zaug exenatide, uas yuav tsum tau txhaj ob hnub subcutaneously ua ntej noj mov thawj zaug thiab zaum kawg ntawm hnub, liraglutide tau pom zoo raws li kev kho mob ib zaug ib hnub thiab tuaj yeem siv ua ke nrog metformin lossis sulfonylurea hauv cov neeg mob uas tsis muaj glycemic tswj nrog ob qho tib si. monotherapy los yog ua ke ob txoj kev kho.Nws kuj tau pom zoo ua ke nrog kev kho dual ntawm metformin thiab thiazolidinedione hauv cov neeg mob uas tsis txaus glycemic tswj.Liraglutide tso tawm qhov kev sib txuas ntawm 61 pM (EC50 = 55 pM rau GLP-1) rau tib neeg cloned GLP-1 receptor.


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    Liraglutide CAS 204656-20-2