Cov khoom

Linagliptin Intermediate F, tseem hu ua 3-aminopiperidine-1-carboxylic acid, yog cov tshuaj tseem ceeb hauv kev sib txuas ntawm linagliptin, tshuaj siv los kho hom 2 mob ntshav qab zib mellitus.Linagliptin belongs rau ib chav kawm ntawm cov tshuaj hu ua dipeptidyl peptidase-4 (DPP-4) inhibitors, uas pab tswj cov ntshav qab zib theem.Linagliptin Intermediate F ua lub luag haujlwm tseem ceeb hauv cov theem kawg ntawm kev sib txuas ntawm linagliptin.Nws ua haujlwm ua lub tsev tseem ceeb los tsim cov qauv tshuaj lom neeg tshwj xeeb ntawm linagliptin los ntawm kev ua haujlwm ntawm cov tshuaj tiv thaiv.Qhov nruab nrab no yog siv tshwj xeeb hauv kev sib txuas ntawm cov tub ntxhais piperidine nplhaib ntawm linagliptin cov qauv molecular.Ib zaug ua ke, linagliptin ua los ntawm inhibiting cov enzymatic kev ua ntawm DPP-4.DPP-4 inhibitors ua haujlwm los ntawm kev tiv thaiv kev ua txhaum ntawm cov tshuaj hormones incretin, xws li glucagon-zoo li peptide-1 (GLP-1), uas yog lub luag haujlwm rau stimulating insulin tso tawm thiab suppressing glucagon secretion.Los ntawm inhibiting DPP-4, linagliptin prolongs qhov kev txiav txim ntawm cov tshuaj hormones incretin, ua rau kev txhim kho cov ntshav qab zib hauv cov tib neeg uas muaj ntshav qab zib hom 2.Linagliptin feem ntau yog muab los ntawm kev noj zaub mov thiab kev tawm dag zog hauv kev tswj ntshav qab zib hom 2.Nws yog lub npe hu rau nws ntev ib nrab-lub neej, uas tso cai rau ib zaug-hnub dosing yooj yim.Linagliptin tau pom zoo kom txo qis hemoglobin A1c qib, ib qho cim ntawm kev tswj cov piam thaj ntev ntev, thiab feem ntau ua rau cov neeg mob tau txais txiaj ntsig zoo. uas tuaj yeem cuam tshuam rau lub neej ntawm cov tib neeg uas muaj ntshav qab zib hom 2.Los ntawm kev koom tes rau kev tsim cov linagliptin cov qauv tshuaj tshwj xeeb, qhov nruab nrab no ua rau cov khoom kawg ua kom zoo inhibit DPP-4 thiab txhim kho glycemic tswj. siv rau kev kho mob ntshav qab zib hom 2.Nws lub luag haujlwm hauv kev tsim cov linagliptin cov qauv molecular underscores nws qhov tseem ceeb hauv kev tsim cov tshuaj uas tuaj yeem txhim kho cov ntshav qab zib thiab txhim kho kev tswj ntshav qab zib.Los ntawm inhibiting DPP-4, linagliptin pab tswj cov ntshav qabzib thiab pab txhawb kev noj qab haus huv tag nrho ntawm cov neeg mob ntshav qab zib hom 2.