L-Tryptophan Cas: 73-22-3 99% Dawb hmoov
| Catalog Number | xwm 90295 |
| Khoom npe | L-Tryptophan |
| CAS | 73-22-3 : kuv |
| Molecular Formula | C11H12N2O2 |
| Molecular Luj | 204.22518 |
| Cov ntaub ntawv khaws cia | Ambient |
| Harmonized tariff Code | 2933980 :ib |
Khoom Specification
| Assay | 99% min |
| Qhov tshwm sim | Dawb hmoov |
| Qib | USP32 |
| Kev sib hloov tshwj xeeb | -29.4 - 32.8 |
| pH | 5.5 rau 7.0 |
| Fe | <0.003% |
| Pb | <0.0015% |
| Poob rau ziab | <0.3% |
| Residue ntawm Ignition | 0.1% max |
| Cl | 0.05% max |
Indoleamine 2,3-dioxygenase (IDO1) thiab tryptophan 2,3-dioxygenase (TDO) yog ob qho kev sib txawv ntawm cov enzymes uas muaj cov ntaub so ntswg sib txawv thiab lub luag haujlwm ntawm lub cev, tab sis ob qho tib si catalyze hloov pauv ntawm tryptophan rau N-formylkynurenine (NFK).IDO1 tau raug kuaj xyuas raws li lub hom phiaj me me rau kev mob qog noj ntshav, thaum cov kev tshawb fawb ua ntej qhia tias TDO yuav yog lub hom phiaj rau kev kho mob qog noj ntshav thiab kab mob neurodegenerative.Peb tau tsim qhov kev ntsuam xyuas siab tshaj plaws rau IDO1 thiab TDO raws li kev sojntsuam tshuaj tshiab, NFK Green, uas cuam tshuam tshwj xeeb nrog NFK los tsim cov xim ntsuab fluorescent molecule nrog lub zog siab ntawm 400 nm thiab emission wavelength ntawm 510 nm.Peb muab thawj qhov kev sib piv ntawm ib sab ntawm ntau qhov luam tawm inhibitors ntawm IDO1 thiab TDO thiab nthuav tawm tias preclinical IDO1 inhibitor Compound 5l qhia tau hais tias muaj kev cuam tshuam loj heev nrog TDO, thaum cov txheeb ze xaiv ntawm lwm cov inhibitors luam tawm tau lees paub.Qhov tsim nyog rau kev soj ntsuam siab ntawm qhov kev ntsuam xyuas tau pom los ntawm kev tshuaj xyuas lub tsev qiv ntawv ntawm 87,000 cov tshuaj lom neeg hauv 384- lossis 1536-zoo hom.Thaum kawg, peb pom tau hais tias qhov kev ntsuam xyuas kuj tuaj yeem siv los ntsuas lub peev xwm ntawm cov hlwb los metabolize tryptophan thiab ntsuas cov cellular potency ntawm IDO1 thiab TDO inhibitors.
