Cov khoom

Ornithine aspartate yog thawj qhov chaw kho mob siv rau kev kho mob hangover thiab hepatic encephalopathy.Nrog rau kev sib sau ua ke ntawm kev siv tshuaj kho mob, ornithine aspartate tau siv dav hauv kev kho mob ntawm daim siab kab mob, thiab tau ua tiav cov txiaj ntsig zoo ntawm cov kab mob siab hepatic encephalopathy, tshuaj ua rau lub siab puas tsuaj, daim siab rog, kab mob siab ntev thiab lwm yam kab mob, tau dav dav. lees paub los ntawm cov kws kho mob.

Ornithine aspartate muab lub substrate rau urea thiab glutamine synthesis hauv vivo.Glutamine yog cov khoom detoxification ntawm ammonia, nrog rau kev cia thiab thauj daim ntawv ntawm ammonia.Nyob rau hauv physiological thiab pathological tej yam kev mob, lub synthesis ntawm urea thiab cov synthesis ntawm glutamine yog cuam tshuam los ntawm ornithine, aspartic acid thiab lwm yam dicarboxyl tebchaw.Ornithine koom nrog yuav luag tag nrho cov txheej txheem ntawm kev ua kom lub voj voog urea thiab tshem tawm cov tshuaj ammonia.Arginine yog tsim nyob rau hauv cov txheej txheem no, thiab urea yog ces sib cais los ua ornithine.Aspartic acid koom nrog hauv kev sib txuas ntawm nucleic acid hauv hepatocytes los pab txhim kho cov hepatocytes puas.Tsis tas li ntawd, vim qhov kev txhawb nqa tsis ncaj ntawm aspartic acid ntawm cov txheej txheem metabolic ntawm tricarboxylic acid nyob rau hauv daim siab hlwb, nws txhawb zog synthesis nyob rau hauv daim siab hlwb, uas yog conducive rau kho cov puas siab puas ntsws hlwb thiab accelerates lub rov qab ntawm daim siab ua haujlwm.Kev nce qib tsis ntev los no tau pom tias aspartate tuaj yeem cuam tshuam cov kev ua ntawm inflammasomes los ntawm N-methyl-D-aspartate (NMDA) receptors, yog li txo cov tshuaj pharmacological ntawm daim siab mob teb.NMDA receptors yog ib qho subtype ntawm ionotropic excitatory glutamate receptors, uas ua lub luag haujlwm tseem ceeb hauv cov txheej txheem physiological xws li kev sib kis ntawm synaptic, synaptic plasticity, kev kawm thiab kev nco hauv nruab nrab paj hlwb.Cov kev tshawb fawb pathological tom qab kuj tau lees paub tias aspartate tau txhim kho cov kab mob hauv daim siab.

Daim ntawv thov kev kho mob

Hauv cov kab mob siab: Ornithine aspartate tau dav siv los ua cov tshuaj tiv thaiv kab mob thiab tshuaj hepatoprotective hauv kev kho mob ntawm ntau yam kab mob siab, xws li kab mob siab encephalopathy, tshuaj ua rau lub siab puas tsuaj, daim siab rog, kab mob siab ntev, thiab lwm yam. ntshav ammonia nyob rau hauv cov neeg mob nrog encephalopathy thiab kev kho mob ntawm neuropsychiatric cov tsos mob maj mam dhau los ua cov tshuaj tseem ceeb rau kev kho mob ntawm ntau yam kab mob siab.

Ornithine aspartate yog ib qho tseem ceeb substrate rau synthesis ntawm urea thiab glutamine.Ornithine tuaj yeem qhib cov enzymes tseem ceeb hauv cov txheej txheem ntawm urea synthesis - ornithine carbamoyltransferase thiab carbamoyl phosphate synthase, thiab txhawb nqa ammonia Metabolism kom ua tiav detoxification ntawm cov ntshav ammonia, aspartic acid raws li lub substrate tuaj yeem tsim glutamic acid thiab oxaloacetic acid cov khoom detification, glutamine. ammonia, thiab nws kuj yog kev cia thiab kev thauj mus los ntawm ammonia.Oxaloacetate koom nrog hauv lub voj voog tricarboxylic acid, txhawb kev tsim hluav taws xob hauv daim siab hlwb, thiab ua rau lub siab puas hlwb raug kho, rov tsim dua tshiab, thiab rov ua lub siab ua haujlwm.Ornithine aspartate tuaj yeem txhim kho daim siab ua haujlwm zoo, txo cov ntshav ammonia, thiab txo qis ammonia nrog lactulose thiab ofloxacin, yog li txhim kho tus nqi kho mob hepatic encephalopathy, uas tsim nyog rau kev siv tshuaj kho mob.

Oncology: Nrog kev hloov pauv tas mus li ntawm hom thiab koob tshuaj ntawm cov tshuaj kws khomob, cov teeb meem cuam tshuam nrog cov tshuaj siv tshuaj khomob kuj tshwm sim, thiab daim siab puas yog ib qho kev puas tsuaj ntawm lub cev.Thaum lub siab puas tsuaj tshwm sim, nws yuav cuam tshuam rau lub cev thiab lub hlwb kev noj qab haus huv ntawm cov neeg mob mus rau qhov sib txawv, cuam tshuam rau kev siv tshuaj tua kab mob, thiab ua rau tsis muaj zog ntawm cov tshuaj khomob.Hauv cov xwm txheej hnyav, daim siab tsis ua haujlwm yuav ua rau muaj kev phom sij rau lub neej.Ornithine aspartate tuaj yeem txhim kho daim siab puas tsuaj los ntawm kev siv tshuaj khomob thiab txhim kho cov nyhuv kho ntawm cov neeg mob qog.

Kev ua haujlwm phais mob: Kev phais phais yog lub tshuab rau tag nrho lub cev hauv nruab nrog cev ntawm tus neeg mob, thiab kev ua haujlwm ntawm lub siab tom qab kev puas tsuaj kuj yog ib qho teeb meem tshwm sim.Ornithine aspartate tuaj yeem tiv thaiv thiab kho lub siab ua haujlwm tom qab lub siab thiab txhawb nqa cov neeg mob rov qab los.