L-lysine dihydrochloride CAS: 657-26-1 99% Dawb crystalline hmoov
| Catalog Number | xwm 90307 |
| Khoom npe | L-lysine dihydrochloride |
| CAS | 657-26-1 : kuv |
| Molecular Formula | C6H14N2O2.2 [HCl] |
| Molecular Luj | 219.10944 ib |
| Cov ntaub ntawv khaws cia | Ambient |
| Harmonized tariff Code | 29224100 ib |
Khoom Specification
| Melting Point | 200-205 ° C |
| Dej | <0.5% |
| Kev sib hloov kho qhov muag | + 15.9 |
| Qhov tshwm sim | Dawb crystalline hmoov |
| Assay (Titration ex Chloride) | > 99% |
Nuclear tsub zuj zuj ntawm ib tug mutant daim ntawv ntawm lub nuclear protein Lamin-A, hu ua Progerin (PG) los yog Lamin AΔ50, tshwm sim nyob rau hauv Hutchinson-Gilford Progeria Syndrome (HGPS) los yog Progeria, ib tug ceev kev laus kab mob.Ib qho ntawm cov tsos mob tseem ceeb ntawm cov kab mob caj ces no yog kev poob ntawm cov roj subcutaneous vim yog qhov ua rau lipodystrophy.Peb stably induced cov kev qhia ntawm tib neeg PG thiab GFP -Green Fluorescent Protein- raws li kev tswj nyob rau hauv 3T3L1 hlwb siv lub lentiviral system los kawm cov Cov nyhuv ntawm PG qhia nyob rau hauv qhov sib txawv muaj peev xwm ntawm cov kab cell no, ib qho ntawm cov qauv siv adipogenic tshaj plaws.Quantitative proteomics (iTRAQ) tau ua los kawm txog cov txiaj ntsig ntawm PG accumulator.Ob peb ntawm cov proteins modulated tau raug lees paub los ntawm immunoblotting thiab PCR real-time.Mitochondrial kev ua haujlwm tau txheeb xyuas los ntawm kev ntsuas ntawm a) mitochondrial basal kev ua haujlwm, b) superoxide anion ntau lawm thiab c) tus neeg ua haujlwm ntawm qhov sib txawv ntawm txoj kev ua pa. txo qhov kev loj hlob ntawm tus nqi thiab mus rau qhov tsis xws luag hauv lub peev xwm adipogenic thaum piv rau kev tswj.Kev soj ntsuam ntau ntawm proteomics pom 181 cov protein ntau (p <0.05) hloov kho hauv PG-expressing preadipocytes.Mitochondrial muaj nuj nqi yog impaired hauv PG-expressing hlwb.Tshwj xeeb, peb tau kuaj pom qhov nce hauv kev ua haujlwm ntawm txoj haujlwm I thiab kev tsim tawm ntau dhau ntawm Superoxide anion.Incubation with Reactive Oxygen Species (ROS) scavenger agents drives down in autophagic proteolysis as displayed by LC3-II/LC3-I ratio.PG qhia nyob rau hauv 3T3L1 hlwb txhawb kev hloov nyob rau hauv ntau yam Biological txheej txheem, nrog rau cov qauv ntawm cytoskeleton, lipid metabolism, calcium. kev tswj hwm, kev txhais lus, protein folding thiab lub zog tsim los ntawm mitochondria.Peb cov ntaub ntawv ntxiv dag zog rau kev koom tes ntawm ROS tsub zuj zuj mus rau kev laus ntxov ntxov phenotype thiab tsim kom muaj kev sib txuas ntawm mitochondrial dysfunction thiab poob ntawm proteostasis hauv HGPS.
