Cov khoom

Ivermectin (Cardomec, Eqvalan, Ivomec) yog ib qho kev sib xyaw ntawm 22,23-dihydro derivatives ntawm avermectins B1a thiab B1b npaj los ntawm catalytic hydrogenation.Avermectins yog cov tswv cuab ntawm tsev neeg ntawm cov txheej txheem complex tshuaj tua kab mob tsim los ntawm fermentation nrog ib hom Streptomycesavermitilis.Lawv qhov kev tshawb pom tau tshwm sim los ntawm kev tshuaj xyuas ntau ntawm kab lis kev cai rau cov neeg ua haujlwm anthelmintic los ntawm naturalsources.Ivermectin yog nquag siv nyob rau hauv tsawg npaum li cas tawm tsam ntau yam ntawm nematodes thiab arthropods uas parasitizeanimals.
Ivermectin tau ua tiav kev siv dav hauv kev kho tsiaj hauv Tebchaws Meskas thiab ntau lub tebchaws thoob plaws ntiaj teb rau kev tswj hwm ntawm endoparasites thiab ectoparasitesin tsiaj nyeg.Nws tau pom muaj txiaj ntsig zoo rau kev kho mob ntawm onchocerciasis ("dej qhov muag tsis pom kev") hauv tib neeg, ib qho kab mob tseem ceeb tshwm sim los ntawm cov kab mob roundwormOncocerca volvulus, uas muaj nyob rau sab hnub poob thiab Central Africa, Middle East, thiab South thiab Central America.Ivermectin rhuav tshem cov microfilariae, tsis paub tab. Cov ntaub ntawv ntawm cov nematode, uas tsim cov tawv nqaij thiab cov nqaij mos nodules uas yog cov yam ntxwv ntawm tus kab mob thiab tuaj yeem ua rau dig muag.Kev tshawb fawb ntawm cov txheej txheem ntawm kev ua ntawm ivermectin qhia tias nws thaiv interneuron-motor neuron kis tau tus mob hauv nematodes los ntawm stimulating qhov tso tawm ntawm inhibitory neurotransmitter GABA.Cov tshuaj tau tsim muaj los ntawm cov chaw tsim khoom ona humanitarian hauv paus rau kev tsim nyog kho cov kev pab cuam los ntawm World Health Organization.

Ivermectin muaj cov haujlwm dav dav hauv qhov uas nws tuaj yeem cuam tshuam rau nematodes, kab, thiab kab mob acarine.Nws yog cov tshuaj xaiv nyob rau hauv onchocerciasis thiab yog heev pab tau nyob rau hauv kev kho mob ntawm lwm yam kab mob filariasis, strongyloidiasis, ascariasis, loiasis, thiab cutaneous larva migrans.Nws kuj tseem muaj zog tiv thaiv ntau yam kab mob.Nws yog cov tshuaj ntawm kev xaiv hauv kev kho cov tib neeg muaj kab mob Onchocerca volvulus, ua raws li cov tshuaj microfilaricidal tawm tsam cov kab mob ntawm daim tawv nqaij (microfilaria).Kev kho txhua xyoo tuaj yeem tiv thaiv qhov muag tsis pom los ntawm ocular onchocerciasis.Ivermectin yog qhov pom tseeb zoo dua li diethylcarbamazine hauv bancroftian filariasis, thiab nws txo qis microfilaremia mus rau zero qib.Hauv brugian filariasis diethylcarbamazine-induced clearance yuav zoo dua.Nws kuj yog siv los kho cov kab mob cutaneous larva migrans thiab tshaj tawm muaj zogyloidiasis.Nws txoj kev nyab xeeb siv thaum cev xeeb tub tsis tau tsim kom tiav.