Folic Acid Cas: 59-30-3 99%
| Catalog Number | xwm 90435 |
| Khoom npe | Folic Acid |
| CAS | 59-30-3 ib |
| Molecular Formula | C19H19N7O6 |
| Molecular Luj | 441.40 Nws |
| Cov ntaub ntawv khaws cia | Ambient |
| Harmonized tariff Code | 29362900 ib |
Khoom Specification
| Qhov tshwm sim | Yellow lossis txiv kab ntxwv crystalline hmoov |
| Assay | 99% |
| Dej | 5.0 - 8.5% |
| Chromatographic purity | <2.0% |
| Solubility | Xyaum insoluble hauv dej thiab feem ntau cov organic solvents.Nws dissolves nyob rau hauv dilute acids thiab nyob rau hauv alkaline daws |
| Residue ntawm Ignition | <0.3% |
Hauv txoj kev tshawb no, thermosensitive thiab folate functionalized poly (ethylene oxide)-b-poly (propylene oxide)-b-poly (ethylene oxide)-ploy (N-isopropylacrylamide-co-hydroxyethyl methacrylate) (FA-Pluronic-PNH) copolymer yog ua ke.Cov qauv thiab qhov hnyav molecular ntawm cov copolymer tau lees paub los ntawm 1H NMR, FT-IR thiab GPC, feem.Qhov ntsuas kub tseem ceeb qis (LCST) ntawm cov copolymer yog 39.8 degrees C. Los ntawm kev siv doxorubicin (DOX) ua cov qauv tshuaj, folate receptor-targeted DOX-loaded micelles tau tsim ntxiv rau ntawm cov copolymer.Cov dawb paug thiab DOX-loaded micelles ob qho tib si nthuav tawm ze li cov duab puab thiab lawv cov kab nruab nrab yog 35 nm thiab 50 nm, feem.Kev coj cwj pwm hauv vitro tso tawm ntawm DOX-loaded micelles yog qhov kub thiab txias ntawm DOX ntawm 42 degrees C (saum LCST) sai dua li ntawm 37 degrees C (hauv qab LCST).Tsis tas li ntawd, kev soj ntsuam cytotoxicity ntawm dawb DOX thiab DOX-loaded micelles ntawm tib neeg lub ncauj tsev menyuam kab mob qog noj ntshav HeLa thiab tib neeg lub ntsws qog nqaij hlav hlwb kab A549 tau qhia tias folate nce cellular uptake ntawm micelles hauv cov hlwb uas tau nthuav tawm ntau tshaj folate receptors.
