Cov khoom

Kev ua tau zoo ntawm cov tshuaj tua kab mob molecules hauv kev kho mob Pseudomonas aeruginosa pneumonia yog txo vim qhov kev nthuav tawm ntawm cov kab mob tsis zoo.Lub neej ntawm cov kab mob sib txuas lus, xws li quorum sensing, tau muab txoj hauv kev tshiab ntawm kev kho mob.Lactonases muaj txiaj ntsig quench acyl-homoserine lactone-based bacterial quorum sensing, implicating cov enzymes li tej zaum cov tshuaj tiv thaiv Pseudomonas tshiab uas tej zaum yuav raug soj ntsuam nyob rau hauv mob ntsws.Lub hom phiaj ntawm txoj kev tshawb no yog los ntsuam xyuas lub peev xwm ntawm lactonase hu ua SsoPox-I kom txo tau. Kev tuag ntawm tus nas P. aeruginosa pneumonia.To soj ntsuam SsoPox-I-mediated quorum quenching, peb thawj zaug ntsuas qhov kev ua ntawm cov kab mob virulence lasB, cov synthesis ntawm pyocianin, cov kev ua ntawm proteolytic kev ncua ntawm cov kab mob thiab tsim ntawm biofilm ntawm ib tug kab mob. PAO1 strain zus nyob rau hauv lub xub ntiag ntawm lactonase.Nyob rau hauv tus qauv mob tuag tes tuag taw ntawm P. aeruginosa pneumonia nyob rau hauv nas, peb tau soj ntsuam qhov tshwm sim ntawm kev kho mob thaum ntxov lossis ncua kev kho mob hauv plab nrog SsoPox-I ntawm kev tuag, kev suav ntawm cov kab mob ntsws thiab lub ntsws puas.SsoPox-I txo qis PAO1 lasB virulence noob kev ua haujlwm , pyocianin synthesis, kev ua haujlwm proteolytic thiab tsim biofilm.Kev siv thaum ntxov ntawm SsoPox-I txo qhov kev tuag ntawm nas nrog mob ntsws los ntawm 75% mus rau 20%.Histological ntsws puas tau txo qis tab sis cov kab mob ntsws suav tsis tau hloov kho los ntawm kev kho mob.Kev kho mob qeeb tau cuam tshuam nrog kev txo qis ntawm kev tuag tsis tseem ceeb.Cov txiaj ntsig no qhia txog kev tiv thaiv ntawm lactonase SsoPox-I hauv P. aeruginosa pneumonia thiab qhib txoj hauv kev rau kev siv tshuaj kho mob yav tom ntej.