Dirhodium tetraacetate CAS: 15956-28-2 99% Ntsuab-dub crystals
| Catalog Number | xwm 90641 |
| Khoom npe | Dirhodium tetraacetate hmoov |
| CAS | 15956-28-2 |
| Molecular Formula | C8H12O8Rh2 |
| Molecular Luj | 441.987 ib |
| Cov ntaub ntawv khaws cia | Ambient |
| Harmonized tariff Code | 28439000 ib |
Khoom Specification
| Qhov tshwm sim | Ntsuab-dub crystals |
| Assay | 99% |
N7/O6 equatorial binding kev sib cuam tshuam ntawm antitumor active complex Rh(2)(OAc)(4)(H(2)O)(2) (OAc(-) = CH(3)CO(2)(-)) nrog DNA fragment d (GpG) tau txiav txim siab tsis meej los ntawm NMR spectroscopy.Yav dhau los X-ray crystallographic kev txiav txim ntawm lub taub hau-rau-lub taub hau (HH) thiab lub taub hau-rau-tail (HT) adducts ntawm dirhodium tetraacetate nrog 9-ethylguanine (9-EtGH) qhia unprecedented bridging N7 / O6 guanine nucleobases uas hla Rh -Rh daim ntawv cog lus.Qhov tsis muaj N7 protonation ntawm qis pH thiab qhov tseem ceeb nce hauv acidity ntawm N1-H (pK(a) kwv yees li 5.7 piv rau 8.5 rau N7 tsuas yog khi platinum adducts), qhia los ntawm pH dependence titrations ntawm purine H8 (1 ) H NMR resonances rau Rh(2)(OAc)(2)(9-EtG)(2) and Rh(2)(OAc)(2-)[d(GpG)], yog zoo ib yam nrog bidentate N7/O6 binding ntawm guanine nucleobases.Cov pK(a) tus nqi kwv yees rau N1-H (de)protonation, los ntawm kev tshawb fawb pH ntawm C6 thiab C2 (13)C NMR resonances rau Rh(2)(OAc)(2)(9-EtG)( 2) isomers, concur nrog t hose muab los ntawm H8 (1) H NMR resonance titrations.Kev sib piv ntawm (13)C NMR resonances ntawm C6 thiab C2 rau dirhodium adducts Rh(2)(OAc)(2)(9-EtG)(2) thiab Rh(2)(OAc)(2)[d(GpG) )] nrog rau cov kev sib raug zoo ntawm cov ligands tsis sib haum [ntawm pH 7.0 rau 9-EtGH thiab pH 8.0 rau d(GpG)], qhia tau hais tias muaj ntau qhov kev hloov pauv ntawm Deltadelta kwv yees li 11.0 thiab 6.0 ppm rau C6 thiab C2, feem;Cov kev hloov tom kawg qhia txog cov txiaj ntsig ntawm O6 khi rau cov chaw dirhodium thiab qhov kev txhim kho ntxiv hauv acidity ntawm N1-H.Nthuav H8 / H8 ROE hla-peaks hauv 2D ROESY NMR spectrum ntawm Rh(2)(OAc)(2)[d(GpG)] qhia taub hau-rau-lub taub hau kev npaj ntawm guanine bases.Lub Rh(2)(OAc)(2)[d(GpG)] adduct nthuav tawm ob tug loj sab tes xis conformers, HH1 R thiab HH2 R, nrog HH1 R yog peb npaug ntau tshaj qhov txawv HH2 R. Ua kom tiav cov yam ntxwv ntawm ob qho tib si. adducts qhia txog kev rov ua dua ntawm 5'-G qab zib rings rau C3'-endo (N-type), tuav ntawm C2'-endo (S-type) conformation rau 3'-G qab zib rin gs, thiab tiv thaiv kev taw qhia txog kev hwm. cov glycosyl bonds.Cov yam ntxwv nta tau txais rau Rh(2)(OAc)(2))[d(GpG)] los ntawm NMR spectroscopy zoo ib yam li cov rau cis-[Pt(NH(3))(2))[d( GpG)]] thiab corroborate molecular qauv kev tshawb fawb.
