Clozapine N-oxide CAS: 34233-69-7
| Catalog Number | xwm 90469 |
| Khoom npe | Clozapine N-oxide |
| CAS | 34233-69-7 |
| Molecular Formula | C18H19ClN4O |
| Molecular Luj | 342.823 ib |
| Cov ntaub ntawv khaws cia | 2 txog 8 ° C |
| Harmonized tariff Code | 293359 0 |
Khoom Specification
| Melting Point | 190-248 ° C |
| Qhov tshwm sim | Dawb hmoov |
| Assay | 99% |
Kev cuam tshuam tsis zoo yog qhov tseem ceeb rau kev sib tham txog qhov tsis zoo rau kev quav tshuaj yeeb tshuaj raws li kev cuam tshuam los ntawm kev mob siab rau kev tsim txom opiate nrog kev nyuaj siab loj (MDD).Cov qauv nas cuam tshuam nrog amygdala prodynorphin (Pdyn) ua tus neeg nruab nrab ntawm kev cuam tshuam tsis zoo;Txawm li cas los xij, pov thawj ntawm PDYN kev koom tes hauv tib neeg tsis zoo cuam tshuam yog txwv.Ntawm no, peb pom txo qis PDYN mRNA qhia nyob rau hauv postmortem human amygdala nucleus ntawm periamygdaloid cortex (PAC) nyob rau hauv ob qho tib si heroin abusers thiab MDD cov ntsiab lus.Zoo ib yam li tib neeg, cov nas uas ua rau tus kheej tus kheej tswj hwm tus kheej tau txo qis Pdyn mRNA qhia hauv PAC ntawm lub sijhawm cuam tshuam nrog lub xeev tsis zoo.Siv cov cuab yeej siv hauv vivo ua haujlwm DREAMM (DREADD-pab metabolic mapping, qhov twg DREADD qhia cov neeg tsim khoom tsim tshwj xeeb tshwj xeeb los ntawm cov tshuaj tsim qauv), peb pom tias xaiv inhibition ntawm Pdyn-expressing neurons hauv nas PAC nce metabolic kev ua haujlwm hauv kev ncua amygdala, uas. yog ib qho tseem ceeb substrate ntawm extrahypothalamic hlwb kev nyuaj siab system.Nyob rau tib lub sijhawm, PAC tshwj xeeb Pdyn inhibition ua rau muaj kev cuam tshuam tsis zoo cuam tshuam txog kev hloov pauv ntawm lub cev thiab kev coj cwj pwm.Ua ke, peb txoj kev tshawb nrhiav kev txhais lus txhawb nqa lub luag haujlwm ua haujlwm rau Pdyn tsis zoo hauv PAC hauv kev tsim txom opiate los ntawm kev ua kom muaj kev ntxhov siab thiab tsis zoo cuam tshuam rau neurocircuitry cuam tshuam rau kev quav yeeb quav tshuaj.
