Cov khoom

Cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride yog ib qho tshuaj lom neeg uas nrhiav tau daim ntawv thov hauv thaj chaw tshuaj chemistry thiab kev tsim tshuaj.Nws cov qauv molecular muaj ib lub nplhaib pyrrolidine nrog tert-butyl pawg ntawm cis txoj hauj lwm, ib pawg ethyl, thiab ob pawg carboxylate.Cov tshuaj no feem ntau pom muaj nyob rau hauv daim ntawv ntawm hydrochloride ntsev.Ib lub ntsiab siv ntawm cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride yog nyob rau hauv cov synthesis thiab kev loj hlob ntawm cov tshuaj tsom lub hauv paus. lub paj hlwb (CNS).Lub xub ntiag ntawm lub nplhaib pyrrolidine, nrog rau tert-butyl thiab ethyl pawg, muab cov khoom sib xyaw no nrog cov khoom muaj peev xwm neuroactive.Cov kws tshawb fawb tuaj yeem siv cov khoom sib xyaw no ua cov khoom pib los tsim cov analogs lossis cov khoom siv uas tuaj yeem xaiv cuam tshuam nrog cov receptors tshwj xeeb lossis cov enzymes hauv CNS.Los ntawm kev hloov kho cov qauv thiab cov khoom siv hloov pauv, lawv tuaj yeem ua kom zoo dua cov khoom siv tshuaj pharmacokinetic, txhim kho nws cov receptor affinity, thiab txhim kho nws cov peev xwm kho mob. Tsis tas li ntawd, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride tuaj yeem ua tau. ua hauj lwm raws li cov cuab yeej sib xyaw hauv cov kev tshawb fawb lom neeg los tshawb xyuas lub luag haujlwm ntawm cov receptors tshwj xeeb lossis cov enzymes hauv cov txheej txheem neurological.Los ntawm kev siv cov tshuaj no ua ib qho ligand lossis kev sojntsuam, cov kws tshawb fawb tuaj yeem kawm txog kev sib raug zoo, kev xaiv, thiab kev ua haujlwm ntawm cov receptors lossis enzymes.Cov ntaub ntawv no yog qhov tseem ceeb rau kev nkag siab txog lub hauv paus molecular ntawm cov txheej txheem neuropharmacological thiab rau kev txhim kho cov kev kho tshiab uas tsom rau cov kab mob neurodegenerative, cov mob puas siab puas ntsws, lossis cov kab mob neurological.Cov compound kuj muaj peev xwm siv hauv kev tshawb nrhiav tshuaj thiab kev tshuaj ntsuam xyuas siab.Nws tuaj yeem muab tso rau hauv cov tsev qiv ntawv ntawm cov tebchaw, uas raug tshuaj xyuas tawm tsam ntau lub hom phiaj, xws li receptors lossis enzymes, txhawm rau txheeb xyuas cov khoom siv lead ua lossis cov neeg sib tw tshuaj.Qhov kev tshuaj ntsuam no tso cai rau kev txheeb xyuas cov tebchaw uas nthuav tawm cov khoom lag luam uas xav tau lossis muaj peev xwm kho tau. Tsis tas li ntawd, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride tuaj yeem pom cov khoom siv hauv kev tsim cov tshuaj.Prodrugs yog cov tsis muaj zog los yog tsis tshua muaj zog sib txuas uas tsim los rau metabolized rau hauv lawv daim ntawv nquag ib zaug hauv lub cev.Los ntawm kev hloov kho cov qauv ntawm qhov sib xyaw no, cov kws tshawb fawb tuaj yeem tsim cov ntaub ntawv prodrug uas ruaj khov dua, txhim kho bioavailability, lossis tuaj yeem hla cov kab mob lom neeg yooj yim dua.Qhov no tuaj yeem txhim kho cov txiaj ntsig kho mob thiab txhim kho nws cov tshuaj pharmacokinetic.Nyob rau hauv cov ntsiab lus, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride yog ib qho sib xyaw nrog cov ntawv thov hauv kev tsim cov tshuaj CNS-targeted tshuaj. , raws li cov cuab yeej siv rau kev tshawb fawb lom neeg, hauv kev tshawb nrhiav tshuaj, thiab hauv kev tsim cov tshuaj.Nws cov qauv molecular tshwj xeeb muaj cib fim rau kev hloov kho thiab kev ua kom zoo los txhim kho nws cov khoom siv tshuaj thiab cov dej num lom neeg.Lub versatility thiab muaj peev xwm ntawm cov compound no ua rau nws yog ib qho cuab tam tseem ceeb hauv kev kho tshuaj chemistry thiab kev txhim kho tshuaj.