Cov khoom

Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride yog ib qho tshuaj lom neeg siv hauv kev tshawb fawb tshuaj thiab kev tsim tshuaj.Nws cov qauv molecular muaj ib pab pawg neeg benzyl txuas nrog cov carbamate ua haujlwm pab pawg los ntawm piperidine moiety.Ib qho kev siv ntawm Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride yog ua ntej. los yog nruab nrab nyob rau hauv lub synthesis ntawm ntau yam tshuaj tebchaw.Lub xub ntiag ntawm lub nplhaib piperidine muab cov khoom sib xyaw no nrog ntau yam hauv cov tshuaj lom neeg cov tshuaj lom neeg, ua rau nws muaj txiaj ntsig zoo pib cov khoom siv rau kev sib xyaw ntawm ntau hom molecules.Los ntawm kev qhia qhov sib xyaw no rau hauv txoj hauv kev sib xyaw, cov kws kho mob tuaj yeem nkag mus rau ntau yam ntawm cov tshuaj tshiab nrog cov kev siv tshuaj kho mob. Tsis tas li ntawd, Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride tuaj yeem siv tau raws li ib lub tsev thaiv rau kev txhim kho cov tshuaj tshiab tsom rau txoj hauv kev lom neeg lossis cov receptors.Nws cov yam ntxwv nta ua rau nws tsim nyog rau kev koom ua ke rau hauv cov tshuaj molecules, ua raws li ib tug pharmacophore los yog ib tug tseem ceeb functional pab pawg neeg lub luag hauj lwm rau cov kev ua ub no.Los ntawm kev hloov kho cov benzyl, piperidine, lossis carbamate Cheebtsam, cov kws tshawb fawb tuaj yeem ua kom zoo dua cov tshuaj muaj zog, kev xaiv, thiab cov khoom siv tshuaj pharmacokinetic.Cov khoom siv kuj tseem tuaj yeem ua cov cuab yeej lossis cov ntaub ntawv siv rau kev tshawb nrhiav tshuaj thiab kev sib raug zoo ntawm kev sib raug zoo (SAR).Los ntawm kev sib piv cov haujlwm lom neeg ntawm ntau yam derivatives lossis analogs ntawm Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride, cov kws tshawb fawb tuaj yeem nkag siab txog cov qauv-kev sib raug zoo, ua rau lawv tsim muaj zog dua. thiab xaiv cov tebchaw.Cov ntaub ntawv no tseem ceeb heev rau kev ua kom zoo ntawm cov hmoov txhuas thiab kev txhim kho cov neeg sib tw tshuaj zoo dua.Ntxiv rau, Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride tuaj yeem siv rau hauv kev tshawb fawb tshuaj chemistry. los kawm txog cov txheej txheem ntawm kev ua ntawm qee yam tshuaj lossis tshawb xyuas cov tshuaj metabolism.Los ntawm kev siv radiolabeled lossis tagged versions ntawm qhov sib xyaw no, cov kws tshawb fawb tuaj yeem taug qab nws cov kev faib tawm thiab cov metabolism hauv cov kab mob lom.Cov ntaub ntawv no pab kom nkag siab tias cov tshuaj tau ua tiav li cas thiab tso tawm hauv lub cev, muab kev nkag siab zoo rau kev sib cuam tshuam tshuaj, kev siv tshuaj ntau npaum li cas, thiab cov tshuaj muaj peev xwm-tshuaj sib cuam tshuam. 2-yl]carbamate hydrochloride yog cov khoom siv ntau yam siv dav hauv kev tshawb fawb tshuaj thiab kev tsim tshuaj.Nws cov yam ntxwv nta ua rau nws muaj txiaj ntsig zoo li lub hauv paus rau kev sib txuas ntawm ntau yam tshuaj sib txuas thiab ua lub tsev thaiv kev tsim cov tshuaj tshiab.Tsis tas li ntawd, nws yog ib qho cuab yeej rau kev tshawb fawb SAR, kev tshawb nrhiav tshuaj, thiab kev tshawb fawb metabolism.Kev siv ntau yam ntawm Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride qhia nws qhov tseem ceeb hauv kev txhim kho cov tshuaj kho tshiab thiab kev nce qib ntawm cov tshuaj chemical.