Cov khoom

Polymer txhuam txheej raws li thaiv copolymer ntawm poly(oligo (ethylene glycol) methacrylate) (POEGMA) thiab poly (glycidyl methacrylate) (PGMA) tau tsim ntawm silicon wafers los ntawm activators generated los ntawm electron hloov atom hloov radical polymerization (AGET ATRP).Ntau hom biomolecule tuaj yeem sib xyaw ua ke rau cov txhuam hniav no los ntawm cov tshuaj tiv thaiv ntawm PGMA epoxide pawg nrog cov amino pawg hauv biomolecule, thaum POEGMA, uas tiv thaiv cov protein tsis tshwj xeeb adsorption, muab qhov chaw tiv thaiv fouling.Qhov saum npoo tau pom los ntawm lub kaum sab xis ntawm dej, ellipsometry, thiab Fourier transform infrared spectroscopy (FTIR) kom paub meej tias cov kev hloov pauv.Phase cais ntawm cov copolymer blocks hauv cov khaubncaws sab nraud povtseg tau pom los ntawm AFM.Cov nyhuv ntawm cov khoom nto ntawm cov protein conjugation tau tshawb xyuas siv cov txheej txheem radiolabeling.Nws tau pom tias qhov chaw nrog POEGMA cov khaubncaws sab nraud povtseg yog cov protein resistant, thaum muaj protein ntau conjugated rau diblock copolymer hloov chaw incre ased nrog nce PGMA txheej thickness.Cov kev ua ntawm lysozyme conjugated rau saum npoo kuj tuaj yeem tswj tau los ntawm kev sib txawv ntawm cov thickness ntawm copolymer txheej.Thaum biotin tau txuas mus rau qhov thaiv copolymer grafts, qhov saum npoo tseem tiv taus cov protein tsis tshwj xeeb adsorption tab sis pom cov kev khi tshwj xeeb ntawm avidin.Cov khoom no, uas yog, tswj kom muaj nuj nqis zoo thiab kev ua haujlwm ntawm kev sib txuas ntawm biomolecules thiab qhov tshwj xeeb ntawm kev sib cuam tshuam nrog lub hom phiaj biomolecules yuav raug siv los txhim kho cov teeb liab-rau- suab nrov piv hauv kev siv sensor.Feem ntau, cov chaw zoo li no yuav muaj txiaj ntsig zoo li kev paub txog keeb kwm ntawm kev ua haujlwm siab rau biomaterials.