Cov khoom

Biofilms yog tsim los ntawm cov kab mob hauv cov kab mob uas muaj nyob rau hauv tus kheej-synthesized, extracellular polymeric matrix.Poly-beta(1,6)-N-acetyl-d-glucosamine (PNAG) yog ib qho tseem ceeb biofilm matrix tivthaiv hauv cov kab mob phylogenetically ntau haiv neeg.Hauv txoj kev tshawb no peb tau tshawb xyuas lub cev thiab tshuaj lom neeg ntawm PNAG matrix hauv biofilms uas tsim hauv vitro los ntawm gram-negative porcine respiratory pathogen Actinobacillus pleuropneumoniae thiab gram-positive device-associated pathogen Staphylococcus epidermidis.Cov nyhuv ntawm PNAG ntawm cov kua dej ntau tau txiav txim siab los ntawm kev ntsuas tus nqi ntawm cov kua convection los ntawm biofilms kab lis kev cai hauv cov khoom siv lim centrifugal.Tus nqi ntawm cov kua dej convection tau nce siab dua hauv biofilms kab lis kev cai nyob rau hauv lub xub ntiag ntawm PNAG-degrading enzyme dispersin B dua li hauv biofilms kab lis kev cai tsis muaj enzyme, qhia tias PNAG txo cov kua dej ntau.PNAG kuj tau thaiv kev thauj mus los ntawm quaternary ammonium compound cetylpyridinium chloride (CPC) los ntawm biofilms.Kev khi ntawm CPC rau biofilms ntxiv impeded kua convection thiab thaiv kev thauj ntawm azo dye Allura liab.Bioactive CPC tau zoo eluted los ntawm biofilms los ntawm kev kho mob nrog 1 M sodium chloride.Ua ke, cov kev tshawb pom no qhia tias CPC reacts ncaj qha nrog PNAG matrix thiab hloov nws lub cev thiab tshuaj.Peb cov txiaj ntsig tau qhia tias PNAG ua lub luag haujlwm tseem ceeb hauv kev tswj hwm lub cev lub cev ntawm biofilms thiab tuaj yeem pab txhawb rau cov txheej txheem biofilm ntxiv xws li biocide tsis kam.