Cov khoom

(4R-Cis)-1,1-Dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol -1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate yog ib qho chaw nrog cov qauv tshuaj complex.Txawm hais tias cov ntaub ntawv tshwj xeeb ntawm kev siv cov khoom sib xyaw no yuav raug txwv, peb tuaj yeem sib tham txog nws cov peev txheej siv raws li nws cov yam ntxwv thiab cov yam ntxwv ntawm cov khoom sib xws.Qhov muaj cov dioxane moiety hauv cov compound no qhia tias nws yuav muaj cov khoom hnyav lossis siv tau. raws li tus neeg sawv cev solubilizing.Dioxane yog ib qho hnyav hnyav, tshwj xeeb tshaj yog nyob rau hauv cov organic chemistry, vim nws yog dej-miscible thiab muaj cov solubility zoo rau ntau yam ntawm cov organic molecules.Lub xub ntiag ntawm dioxane moiety nyob rau hauv cov compound no qhia tau hais tias nws yuav muaj xws li solubility zog. Tsis tas li ntawd, cov yam ntxwv ntawm cov compound no, xws li cov fluorophenyl thiab phenylamino carbonyl pawg, qhia muaj peev xwm ua rau lom lom.Kev hloov fluorine hauv cov organic tebchaw tuaj yeem txhim kho lawv cov tshuaj pharmacokinetic, uas tuaj yeem ua rau lawv cov potency lossis bioavailability.Lub xub ntiag ntawm phenylamino carbonyl pawg yuav qhia tau tias muaj peev xwm sib cuam tshuam nrog cov hom phiaj lom neeg, tejzaum nws ua rau cov teebmeem kev kho mob.Raws li cov yam ntxwv ntawm cov qauv no, nws muaj peev xwm hais tias qhov sib xyaw no yuav muaj kev siv tshuaj chemistry lossis kev tsim tshuaj.Nws tuaj yeem tshawb xyuas raws li cov khoom siv lead ua muaj peev xwm rau kev tsim cov tshuaj tshiab tsom rau cov kab mob tshwj xeeb.Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias yuav tsum muaj kev tshawb fawb ntxiv los txiav txim siab nws cov khoom siv tshuaj, suav nrog nws cov txiaj ntsig, kev ua haujlwm, thiab cov kev mob tshwm sim. los yog ua ib feem nyob rau hauv chemical synthesis.Nitronyl thiab pyrrole derivatives tau raug tshawb xyuas rau lawv cov peev xwm siv los ua cov khoom siv hluav taws xob, cov khoom siv hluav taws xob, lossis cov tsev thaiv rau ntau cov qauv.Txawm li cas los xij, cov ntawv thov no yuav xav tau kev tshawb nrhiav ntxiv thiab kev ua kom zoo ntawm cov txheej txheem synthesis.Tshaj tag nrho, cov compound (4R-Cis)-1,1-Dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-) methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate qhia tau tias muaj peev xwm rau kev siv hauv tshuaj chemistry, cov ntaub ntawv science, los yog chemical synthesis.Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum tau ua ntau yam kev tshawb fawb los ntsuas nws cov khoom, txhim kho txoj hauv kev tsim nyog, thiab txiav txim siab nws cov ntawv thov tshwj xeeb hauv txhua qhov chaw.