Cov khoom

4-Chloro-2-fluoro-3-methoxyphenylboronic acid yog cov tshuaj sib xyaw uas muaj ntau yam kev siv hauv cov organic synthesis, tshuaj chemistry, thiab cov ntaub ntawv science.Ib qho ntawm cov thawj siv ntawm 4-Chloro-2-fluoro-3-methoxyphenylboronic acid yog nyob rau hauv kev hloov hlau-catalyzed cross-coupling tshua.Nws ua haujlwm raws li boronic acid tsev thaiv, tso cai rau tsim cov pa roj carbon-carbon lossis carbon-heteroatom bonds.Piv txwv li, qhov sib xyaw no tuaj yeem siv rau hauv Suzuki-Miyaura cross-coupling cov tshuaj tiv thaiv, qhov twg nws hnov ​​​​mob nrog aryl lossis vinyl halides hauv qab palladium catalysis los tsim cov biaryl tebchaw.Cov kev sib txuas sib txuas no tau siv dav hauv kev sib txuas ntawm cov organic molecules, suav nrog cov tshuaj thiab cov tshuaj agrochemicals, nrog rau kev tsim cov khoom siv organic.Qhov sib xyaw tshwj xeeb ntawm chlorine, fluorine, thiab methoxy pawg hauv cov qauv ntawm 4-Chloro-2. -fluoro-3-methoxyphenylboronic acid ua kom cov synthesis ntawm ntau yam derivatives nrog cov khoom tsim.Cov tshuaj chlorine atom tuaj yeem ua ib pab pawg tswj hwm hauv kev hloov pauv cov txheej txheem hlau-catalyzed, coj cov tshuaj tiv thaiv xaiv rau cov chaw tshwj xeeb hauv cov molecule.Fluorine hloov pauv muab kev txhim kho lipophilicity, uas tuaj yeem cuam tshuam cov khoom siv tshuaj pharmacokinetic thiab txhim kho nws cov bioavailability.Cov pab pawg methoxy, ntawm qhov tod tes, tuaj yeem ua raws li pab pawg tiv thaiv lossis koom nrog ntau yam tshuaj hloov pauv.Nyob hauv tshuaj chemistry, 4-Chloro-2-fluoro-3-methoxyphenylboronic acid thiab nws cov derivatives muaj kev txaus siab raws li cov neeg sib tw siv tshuaj.Cov pab pawg ua haujlwm xws li chlorine thiab fluorine tuaj yeem hloov kho qhov sib xyaw ua ke nrog cov hom phiaj lom neeg thiab txhim kho nws cov khoom siv tshuaj.Tsis tas li ntawd, pawg methoxy tuaj yeem txhim kho qhov sib xyaw ua ke ntawm metabolic stability thiab pab txhawb rau nws lipophilicity thiab solubility.Cov khoom no ua rau 4-Chloro-2-fluoro-3-methoxyphenylboronic acid yog qhov pib muaj txiaj ntsig rau kev tsim cov tshuaj kho tshiab hauv thaj chaw xws li oncology, kab mob sib kis, thiab mob o. Tsis tas li ntawd, boronic acid moiety hauv 4-Chloro-2-fluoro -3-methoxyphenylboronic acid tuaj yeem pab tsim cov boronate esters ruaj khov, uas tau siv los tsim cov khoom siv nrog cov khoom tshwj xeeb.Cov ntaub ntawv no tuaj yeem pom cov khoom siv kho qhov muag, hluav taws xob, lossis catalytic, nyob ntawm seb lawv muaj pes tsawg leeg thiab cov qauv.Kev sib koom ua ke ntawm 4-Chloro-2-fluoro-3-methoxyphenylboronic acid los yog nws cov derivatives rau hauv cov ntaub ntawv no tuaj yeem muab cov haujlwm tshwj xeeb thiab txhim kho lawv cov kev ua tau zoo. vim nws muaj ntau yam chemistry thiab muaj peev xwm tsim cov molecules thiab cov khoom siv.Nws lub luag haujlwm hauv kev hloov pauv hlau-catalyzed coupling cov tshuaj tiv thaiv, ua ke nrog cov khoom tshwj xeeb ntawm nws cov pab pawg ua haujlwm, ua rau nws muaj txiaj ntsig zoo hauv cov organic synthesis thiab tshuaj chemistry.Tsis tas li ntawd, boronic acid moiety ua rau tsim cov boronate esters, uas ua rau kev txhim kho cov ntaub ntawv siab heev nrog cov khoom zoo.