4-Aminophthalhydrazide AMPPD Cas: 3682-14-2 Lub teeb daj rau amber mus rau tsaus ntsuab hmoov rau pob
| Catalog Number | xwm 90156 |
| Khoom npe | 4-Aminophthalhydrazide |
| CAS | 3682-14-2 : kuv |
| Molecular Formula | C8H7N3O2 |
| Molecular Luj | 177.16 Nws |
| Cov ntaub ntawv khaws cia | Khw hauv RT |
Khoom Specification
| Qhov tshwm sim | Lub teeb daj rau amber rau tsaus ntsuab hmoov rau pob |
| Assay | ≥98.0% |
| Qhov ntom | 1.433 ib |
| Melting point | 300 ºC |
| Boiling point | 633 ° C ntawm 760 mmHg |
| Flash point | 336.7°C dej |
| Solubility | Soluble hauv ammonium hydroxide, sodium carbonate lossis lwm yam hauv paus. |
1.Peb soj ntsuam thiab muab piv cov nyhuv ntawm tsib H1-antihistamines ntawm stimulated oxidative burst ntawm extra- thiab intracellular theem ntawm cais thiab stimulated tib neeg polymorphonuclear leukocytes.Oxidative tawg ntawm cais tib neeg neutrophils tau kawm los ntawm txoj kev luminol thiab isoluminol enhanced chemiluminesc. Qib kev txiav txim ntawm potency rau H1-antihistamines kom txo chemiluminescence raug soj ntsuam extracellularly: dithiaden> loratadine> chlorpheniramine> brompheniramine> pheniramine thiab nyob rau hauv intracellular site: loratadine> dithiaden.H1-antihistamines txawv lawv ob qho tib si substantiation ntawm oxidative qauv. - thiab intracellular qhov chaw ntawm cais tawm stimulated tib neeg neutrophils.
2.Chemiluminescence systems txhim kho los ntawm isoluminol lossis luminol hauv kev sib xyaw nrog peroxidase yog cov txheej txheem rhiab rau kev tshawb nrhiav cov pa oxygen reactive (ROS) tsim los ntawm phagocyte NADPH oxidase.Ob lub amplifying substrates yog structurally zoo sib xws, txawv tsuas yog nyob rau hauv txoj hauj lwm ntawm cov amino pawg nyob rau hauv lub aromatic nplhaib ntawm lub molecules.Qhov sib txawv no ua rau isoluminol tsawg lipophilic molecule uas tsis tshua muaj permeable rau cov kab mob lom.Kev siv cov isoluminol yog li txwv rau kev tshawb fawb txog kev zais ntawm oxygen metabolites.Nyob rau hauv txoj kev tshawb no peb qhia tau hais tias hluavtaws peptides muab los ntawm N-terminal domain ntawm calcium-regulated protein annexin AI cuam tshuam nrog kev tshawb pom ntawm radicals nyob rau hauv ib qho isoluminol-amplified, tab sis tsis nyob rau hauv ib tug luminol-amplified, system.Lub annexin AI-derived peptides txo cov teeb pom kev zoo nrog isoluminol zoo siab los ntawm superoxide thiab horseradish peroxidase (HRP) hauv formyl-methionyl-leucyl-phenylalanine- thiab phorbol kuv ristate acetate-stimulated hlwb, nrog rau hydrogen peroxide thiab HRP.Lub meej mechanism rau inhibition tsis paub.Cov txiaj ntsig tau nthuav tawm qhia tau hais tias qhov txo qis ntawm cov xov tooj ntawm tes tau kuaj pom nrog isoluminol-amplified chemiluminescence yuav tsum tau lees paub nrog lwm txoj kev los txiav txim siab tso tawm superoxide anions thiab hydrogen peroxide.
