![4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol CAS: 147118-36-3 Featured duab](http://cdn.globalso.com/xdbiochems/白色粉末1130.jpg)
![4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol CAS: 147118-36-3](http://cdn.globalso.com/xdbiochems/粉末147.jpg)
4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol CAS: 147118-36-3
| Catalog Number | xwm 93412 |
| Khoom npe | 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino] pyrimidine-5-yl-methanol |
| CAS | 147118-36-3 |
| Molecular Formula | C16H20FN3O3S |
| Molecular Luj | 353.41 ib |
| Cov ntaub ntawv khaws cia | Ambient |
Khoom Specification
| Qhov tshwm sim | Dawb hmoov |
| Assay | 99% min |
4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino] pyrimidine-5-yl-methanol, tseem hu ua Z6, yog ib qho tshuaj lom neeg muaj peev xwm siv hauv kev lag luam tshuaj .Nws cov qauv tshwj xeeb thiab cov pab pawg ua haujlwm ua rau nws yog tus neeg sib tw nthuav dav rau kev tshawb nrhiav tshuaj thiab kev txhim kho.Ib qho peev xwm siv Z6 yog ib qho tshuaj tiv thaiv kab mob.Kev mob plab ua lub luag haujlwm hauv ntau yam kab mob, suav nrog mob caj dab rheumatoid, kab mob plab hnyuv, thiab mob hawb pob.Z6's fluoro-hloov phenyl pawg thiab pyrimidine core ua rau nws tsim nyog rau kev sib cuam tshuam nrog cov hom phiaj tshwj xeeb koom nrog hauv cov txheej txheem inflammatory, uas yuav ua rau kev txhim kho cov tshuaj tiv thaiv kab mob tshiab.Z6 kuj tuav cov lus cog tseg raws li tus neeg sawv cev tiv thaiv kab mob.Kev kis kab mob tseem yog qhov tseem ceeb hauv ntiaj teb kev txhawj xeeb txog kev noj qab haus huv, thiab muaj qhov xav tau tas li rau cov kev kho mob tshiab thiab muaj txiaj ntsig zoo.Lub xub ntiag ntawm pawg isopropyl hauv Z6 txhim kho nws cov khoom siv hydrophobic, tso cai rau nws tuaj yeem nkag mus rau cov kab mob sib kis thiab cuam tshuam cov kab mob sib kis.Nws cov yam ntxwv zoo tuaj yeem ua kom zoo rau tshwj xeeb rau cov kab mob enzymes lossis cov proteins, ua rau kev txhim kho cov tshuaj tiv thaiv kab mob muaj zog. Tsis tas li ntawd, Z6 yuav muaj kev siv hauv kev kho mob qog noj ntshav.Cov fluoro-substituted phenyl pawg thiab pyrimidine core feem ntau pom muaj nyob rau hauv cov tebchaw nrog kev tiv thaiv kab mob.Los ntawm kev hloov kho Z6 qauv, nws yuav ua tau los tsim cov derivatives uas xaiv lub hom phiaj mob qog noj ntshav, inhibiting lawv txoj kev loj hlob thiab inducing apoptosis thaum sparing hlwb noj qab nyob zoo.Lub compound lub solubility thiab stability kuj yuav optimized los txhim kho nws cov kev ua tau zoo thiab txo tej yam kev mob tshwm sim. Tsis tas li ntawd, Z6 yuav siv tau raws li ib tug pib taw tes rau cov synthesis ntawm me me molecule tsev qiv ntawv los yog tshuaj scaffolds.Nws muaj qhov yooj yim rau kev hloov kho thiab kev ua kom zoo dua qub, tso cai rau kev tshawb nrhiav cov qauv-kev sib raug zoo thiab kev txheeb xyuas cov khoom siv lead ua rau kev txhim kho txuas ntxiv.Nws cov yam ntxwv nta thiab cov pab pawg ua haujlwm ua rau nws tsim nyog rau ntau yam kev kho mob, suav nrog kev siv tshuaj tua kab mob, tshuaj tua kab mob, thiab tshuaj tiv thaiv kab mob.Nrog rau kev tshawb fawb thiab kev loj hlob ntxiv, Z6 thiab nws cov derivatives tuav lub peev xwm los ua kom muaj txiaj ntsig zoo rau kev tshawb nrhiav tshuaj thiab pab txhawb rau kev txhim kho tshiab thiab kho tau zoo.
