Cov khoom

(3aR,7aR)-4-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1-piperazin]-2-ium4-methylbenzenesulfonate, kuj hu ua cov compound BISO, yog cov tshuaj sib xyaw nrog Cov qauv tshwj xeeb uas qiv nws tus kheej rau ntau qhov kev siv tau hauv thaj chaw tshuaj chemistry thiab kev txhim kho tshuaj.Ob lub peev xwm ntawm BISO yog nyob rau hauv kev kho mob ntawm neurological ntshawv siab.Lub xub ntiag ntawm benzo [d] isothiazol-3-yl moiety nyob rau hauv nws cov qauv qhia tias BISO yuav muaj kev cuam tshuam nrog cov neurotransmitter tshwj xeeb hauv lub hlwb, xws li glutamate lossis GABAergic systems.Cov kab mob neurotransmitter no cuam tshuam rau ntau yam kab mob hauv lub paj hlwb xws li qaug dab peg, ntxhov siab, thiab kev xav tsis zoo.Cov kws tshawb nrhiav tuaj yeem tshawb nrhiav lub peev xwm ntawm BISO los hloov kho cov tshuab no thiab tsim cov tshuaj kho tshiab rau cov kab mob paj hlwb. Tsis tas li ntawd, BISO's spiro [isoindole-2,1-piperazin] cov qauv tseem ceeb muaj peev xwm siv rau hauv kev txhim kho cov tshuaj tsom mus rau ntau yam. cov hom phiaj lom neeg.Nws cov duab peb sab thiab muaj cov pab pawg ua haujlwm tuaj yeem cuam tshuam nrog cov receptors tshwj xeeb lossis cov enzymes, tso cai rau kev tsim cov tshuaj xaiv thiab muaj zog.Cov kws tshawb fawb tuaj yeem siv cov qauv tsim qauv no los tsim cov molecules me me uas lub hom phiaj receptors koom nrog ntau yam kab mob, xws li mob qog noj ntshav, mob plawv, lossis kab mob sib kis. Tsis tas li ntawd, BISO tus qauv spirocyclic thiab them ammonium pawg ua rau nws muaj peev xwm sib tw rau kev xa tshuaj.Lub xub ntiag ntawm ib pab pawg neeg them nyiaj tso cai rau tsim cov ionic complexes nrog tsis zoo nqi molecules, xws li nucleic acids los yog proteins.Cov complexes no tuaj yeem pab txhawb kev xa tawm ntawm bioactive molecules rau hauv cov hlwb lossis cov ntaub so ntswg, txhim kho kev ua haujlwm zoo thaum txo qis cov kev mob tshwm sim.Nws cov qauv tshwj xeeb nthuav tawm cov sijhawm rau cov kws kho mob tshuaj los tshawb txog nws cov khoom siv tshuaj thiab ua kom zoo dua nws lub peev xwm rau kev tshawb nrhiav tshuaj.As nrog rau cov tshuaj lom neeg, kev siv BISO yuav tsum ua raws li cov txheej txheem kev nyab xeeb thiab cov lus qhia.Cov kws tshawb fawb yuav tsum tau ceev faj thaum lub sij hawm nws cov synthesis, tuav, thiab cia kom muaj kev nyab xeeb thiab txo qhov kev pheej hmoo. ]-2-ium4-methylbenzenesulfonate, lossis BISO, tuav cov lus cog tseg rau ntau yam kev siv hauv tshuaj chemistry thiab kev tsim tshuaj.Nws cov qauv tshwj xeeb muab lub sijhawm rau kev tshawb pom ntawm cov tshuaj kho tshiab, lub hom phiaj kev xa tshuaj, thiab kev hloov pauv ntawm cov kab mob neurotransmitter.Txawm li cas los xij, kev tshawb fawb dav dav yog qhov yuav tsum tau ua kom paub meej nws lub peev xwm thiab txhim kho nws txoj kev siv hauv kev kho mob.