Cov khoom

Cerebral dopamine neurotrophic factor (CDNF) protein tau pom los tiv thaiv txoj hauv kev nigrostriatal dopaminergic thaum muab raws li intrastriatal infusions hauv nas thiab nas qauv ntawm Parkinson's disease (PD).Hauv txoj kev tshawb no, peb tau soj ntsuam cov txiaj ntsig neuroprotective ntawm CDNF xa nrog ib qho recombinant adeno-associated viral (AAV) serotype 2 vector hauv nas 6-hydroxydopamine (6-OHDA) qauv ntawm PD.AAV2 vectors encoding CDNF, glial cell line-derived neurotrophic factor (GDNF), lossis ntsuab fluorescent protein tau txhaj rau hauv nas striatum.Kev tsom xam cov protein qhia tau pom tias peb AAV2 vector ua tau zoo xa cov noob caj noob ces neurotrophic mus rau hauv lub hlwb thiab ua rau muaj kev qhia ntev ntev ntawm cov protein.Ob lub lis piam tom qab AAV2 vector txhaj, 6-OHDA tau txhaj rau hauv nas striatum, tsim kom muaj kev loj hlob ntawm cov kab mob nigrostriatal dopaminergic.Kev kho nrog AAV2-CDNF ua rau muaj qhov txo qis hauv amphetamine-induced ipsilateral rotations thaum nws muab tsuas yog ib feem kev tiv thaiv ntawm tyrosine hydroxylase (TH)-immunoreactive hlwb nyob rau hauv cov nas substantia nigra pars compacta thiab TH-reactive fibers nyob rau hauv lub striatum.Cov txiaj ntsig tau los ntawm txoj kev tshawb no muab pov thawj ntxiv tias CDNF tuaj yeem suav tias yog kev kho mob ntawm Parkinson tus kab mob