Cov khoom

2-(3-Formyl-4-hydroxy-phenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester yog cov tshuaj sib xyaw ua ke uas tuav cov lus cog tseg hauv kev lag luam kws tshuaj vim nws cov qauv tshwj xeeb thiab muaj peev xwm ua haujlwm lom neeg.Cov tshuaj no tuaj yeem siv rau hauv ntau yam kev siv tshuaj chemistry thiab cov txheej txheem tshawb nrhiav tshuaj.Ib lub peev xwm siv 2-(3-Formyl-4-hydroxy-phenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester yog cov khoom pib. rau cov synthesis ntawm cov tshuaj tshiab.Nws cov qauv muaj cov pab pawg ua haujlwm uas tuaj yeem hloov kho thiab hloov pauv, tso cai rau cov kws kho mob kom paub cov khoom sib txawv thiab tsim cov molecules sib txawv nrog cov khoom siv tshuaj kho kom zoo.Los ntawm kev hloov kho qhov sib xyaw no, cov kws tshawb fawb tuaj yeem tsim cov tsev qiv ntawv ntawm cov khoom siv rau kev sib raug zoo ntawm kev sib raug zoo (SAR), ntsuas qhov cuam tshuam ntawm ntau yam kev hloov kho ntawm cov tshuaj muaj zog, kev xaiv, thiab cov khoom siv tshuaj pharmacokinetic. Tsis tas li ntawd, cov khoom sib xyaw no tuaj yeem nthuav tawm cov kev ua ub no ntawm nws tus kheej. , uas tuaj yeem tshawb nrhiav rau cov kev siv tshuaj kho tau zoo.Lub xub ntiag ntawm lub nplhaib thiazole thiab ib pab pawg neeg formyl nrog rau phenolic moiety qhia tias nws tuaj yeem muaj cov tshuaj tiv thaiv antioxidant thiab tiv thaiv kab mob.Cov khoom no feem ntau nrhiav tom qab hauv kev tsim tshuaj, vim tias lawv tuaj yeem pab txhawb kev tiv thaiv lossis kev kho mob ntawm ntau yam kab mob ntsig txog oxidative kev nyuaj siab thiab cov txheej txheem inflammatory, xws li mob plawv lossis neurodegenerative mob.The 2-(3-Formyl-4-hydroxy- phenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester kuj tuaj yeem siv rau kev kawm enzyme inhibition thiab enzyme-substrate kev sib cuam tshuam.Enzymes ua lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem lom neeg thiab feem ntau cuam tshuam rau cov kab mob.Los ntawm kev tsim cov analogs ntawm qhov sib xyaw no thiab tshawb xyuas lawv cov kev cuam tshuam nrog cov enzymes tshwj xeeb, cov kws tshawb fawb tuaj yeem nkag siab txog kev ua haujlwm enzymatic thiab muaj peev xwm txheeb xyuas cov hom phiaj tshuaj tshiab, tshwj xeeb tshaj yog rau cov xwm txheej cuam tshuam txog kev ua haujlwm tsis zoo ntawm cov tshuaj enzymatic. .Nws cov qauv tshwj xeeb ua rau nws tsim nyog rau kev tshawb fawb docking thiab qauv molecular, qhov twg cov kws tshawb fawb tuaj yeem kwv yees hom kev sib txuas ntawm cov khoom sib xyaw nrog cov hom phiaj cov protein thiab ua kom zoo dua nws cov kev sib cuam tshuam los txhim kho kev ua tau zoo. -4-methyl-thiazole-5-carboxylic acid ethyl ester qhia tau hais tias muaj peev xwm siv tau hauv tshuaj chemistry thiab tshuaj nrhiav pom.Nws tuaj yeem ua qhov pib muaj txiaj ntsig rau kev sib txuas ntawm cov tshuaj tshiab nrog cov khoom siv tshuaj kho kom zoo.Tsis tas li ntawd, nws muaj peev xwm ua rau muaj kev ua haujlwm lom neeg lom zem thiab kev cuam tshuam nrog cov enzymes ua rau nws yog tus neeg sib tw txaus siab rau kev tshawb nrhiav ntxiv hauv kev siv tshuaj kho mob.Kev tshawb fawb txuas ntxiv thiab kev tshawb nrhiav yuav nthuav tawm tag nrho cov peev txheej ntawm qhov sib xyaw no hauv kev tsim cov tshuaj tshiab thiab nkag siab txog cov txheej txheem lom neeg.