Cov khoom

(1R,2S,5S)—6,6-DiMethyl-3-aza-bicylo[3.1.0]hexane-2-carboxylic acid Methyl ester hydrochloride yog cov tshuaj sib xyaw nrog ntau yam kev siv hauv kev tshawb fawb tshuaj thiab kev tsim tshuaj. Cov kev siv tseem ceeb ntawm qhov sib xyaw no yog raws li lub tsev thaiv chiral hauv kev sib txuas ntawm cov tshuaj intermediates thiab cov khoom xyaw tshuaj nquag (APIs).Nws cov qauv bicyclic tshwj xeeb thiab chirality ua rau nws muaj txiaj ntsig hauv kev tsim cov tshuaj dawb huv enantiomerically.Los ntawm kev sib xyaw cov tshuaj no rau hauv kev sib xyaw ua ke, cov kws kho mob tuaj yeem tswj cov stereochemistry thiab tsim cov tshuaj pharmacological tshwj xeeb hauv cov txiaj ntsig molecules.Qhov no yog qhov tseem ceeb tshwj xeeb hauv kev tsim tshuaj, qhov uas xav tau kev ua haujlwm lom neeg feem ntau yog nyob ntawm qhov chaw ntawm cov molecule.Ntxiv mus, (1R,2S,5S)-6,6-DiMethyl-3-aza-bicylo[3.1.0]hexane -2-carboxylic acid Methyl ester hydrochloride yog siv los ua tus thawj coj rau kev sib txuas ntawm quinuclidine-based tshuaj.Quinuclidine derivatives tau qhia ntau yam kev ua ub no, suav nrog tshuaj tua kab mob, tshuaj tiv thaiv kab mob, thiab tshuaj tua kab mob.Los ntawm kev qhia cov pab pawg ua haujlwm tshwj xeeb rau cov khoom sib xyaw, cov kws kho mob tuaj yeem hloov kho nws cov tshuaj pharmacokinetic thiab cov tshuaj pharmacodynamic, txhim kho nws cov peev xwm kho mob. Tsis tas li ntawd, cov tshuaj no pom siv los ua cov tshuaj reactant lossis catalyst hauv cov organic transformations.Vim tias muaj cov amines tertiary thiab qhov tsis zoo ntawm cov methyl pawg, nws tuaj yeem koom nrog ntau yam tshuaj lom neeg, xws li amidation, alkylation, thiab cycloaddition tshua.Nws cov reactivity thiab muaj peev xwm los tsim complex intermediates ua rau nws ib tug ntau yam cuab yeej nyob rau hauv cov organic synthesis, tso cai rau cov creation ntawm structurally diverse compounds.Nyob rau hauv cov ntsiab lus, (1R,2S,5S)-6,6-DiMethyl-3-aza-bicylo[3.1 .0] hexane-2-carboxylic acid Methyl ester hydrochloride yog ib qho tseem ceeb hauv kev tsim tshuaj thiab cov organic synthesis.Nws cov chirality thiab cov qauv tshwj xeeb tso cai rau kev tsim cov tshuaj dawb huv enantiomerically thiab cov synthesis ntawm quinuclidine-based tshuaj nrog cov khoom siv tshuaj tshwj xeeb.Nws cov reactivity kuj ua rau nws muaj txiaj ntsig zoo reactant thiab catalyst hauv ntau yam tshuaj hloov pauv.Zuag qhia tag nrho, qhov sib xyaw no ua lub luag haujlwm tseem ceeb hauv kev nce qib ntawm kev tshawb fawb tshuaj thiab kev txhim kho cov tshuaj kho tshiab.