Cov khoom

1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine -3-carboxylic acid ethyl ester yog ib tug complex tshuaj compound uas tau pom muaj peev xwm nyob rau hauv ntau qhov chaw ntawm tshuaj chemistry thiab tshuaj nrhiav pom.Ntawm no yog ib qho kev piav qhia ntawm nws siv nyob rau hauv hais txog 300 lo lus.This compound, feem ntau hu ua ethyl ester derivative ntawm 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl) phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid, belongs rau chav kawm ntawm pyrazolo[3,4-c] pyridine derivatives.Cov derivatives no tau nyiam cov tshuaj nrhiav pom vim lawv lub peev xwm hauv ntau qhov chaw kho mob.Ib qho peev txheej ntawm cov tshuaj no yog nyob rau hauv kev tshawb fawb los tiv thaiv qog noj ntshav.Pyrazolo [3,4-c] pyridine derivatives tau nthuav tawm kev cog lus los tiv thaiv kev loj hlob tawm tsam ntau hom mob qog noj ntshav.Lawv lub peev xwm los cuam tshuam txoj hauv kev tshwj xeeb koom nrog hauv cov qog loj hlob thiab muaj sia nyob ua rau lawv muaj peev xwm sib tw rau kev txhim kho cov tshuaj tiv thaiv kab mob.Cov kev tshawb fawb ntxiv yog xav tau los tshawb xyuas cov txheej txheem ntawm kev ua haujlwm thiab ntsuas qhov kev ua tau zoo hauv cov chaw kho mob preclinical thiab chaw kho mob. Tsis tas li ntawd, qhov sib xyaw no tau pom cov lus cog tseg raws li tus neeg sawv cev tiv thaiv kab mob.Nws tau nthuav tawm cov haujlwm tawm tsam ntau hom kab mob, suav nrog cov kab mob Gram-positive thiab Gram-negative.Lub peev xwm los tsom ntau hom kab mob qhia txog nws lub peev xwm hauv kev tawm tsam cov kab mob tshuaj tiv thaiv kab mob, uas tau dhau los ua kev txhawj xeeb txog kev noj qab haus huv thoob ntiaj teb.Kev tshawb fawb ntxiv tau lees paub los tshuaj xyuas nws cov kev ua haujlwm thiab ntsuas nws cov txiaj ntsig hauv kev sib ntaus sib tua kab mob.Ntxiv mus, pyrazolo[3,4-c] pyridine derivatives, suav nrog cov khoom sib xyaw no, tau pom muaj peev xwm hauv kev kho mob ntawm cov kab mob autoimmune.Kev mob tshwm sim ua lub luag haujlwm tseem ceeb hauv ntau yam mob xws li mob caj dab rheumatoid thiab psoriasis.Cov derivatives no tau nthuav tawm cov khoom tiv thaiv kab mob los ntawm kev hloov kho txoj hauv kev tshwj xeeb koom nrog hauv cov lus teb inflammatory.Qhov no qhia tau hais tias lawv muaj peev xwm ua cov tshuaj kho mob rau kev tswj cov mob o thiab cov kab mob sib kis. Tsis tas li ntawd, qhov sib xyaw no tau qhia txog kev ua haujlwm hauv nruab nrab paj hlwb (CNS).Nws tau raug tshawb xyuas rau nws qhov muaj peev xwm ntawm cov kab mob neurological xws li Alzheimer's disease thiab Parkinson's disease.Lub compound tuaj yeem hloov kho cov receptors tshwj xeeb thiab cov enzymes koom nrog hauv kev kis kab mob, muaj peev xwm muab cov teebmeem neuroprotective.Txawm li cas los xij, kev tshawb fawb ntxiv yog xav tau kom nkag siab tag nrho nws cov txheej txheem ntawm kev ua haujlwm thiab ntsuas nws cov txiaj ntsig hauv kev kho cov kab mob nyuaj no. yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester tuav cov lus cog tseg hauv ntau qhov chaw kho mob, suav nrog tshuaj tiv thaiv kab mob, tshuaj tua kab mob, tshuaj tiv thaiv. , thiab CNS mob.Nws lub peev xwm nyob hauv nws lub peev xwm los tsom rau txoj hauv kev tshwj xeeb thiab cov receptors koom nrog hauv cov xwm txheej no.Txawm li cas los xij, kev tshawb nrhiav thiab kev tshawb nrhiav ntxiv yog tsim nyog los tshawb nrhiav nws lub peev xwm, txhim kho nws cov khoom zoo, thiab ntsuas nws txoj kev nyab xeeb thiab kev ua tau zoo hauv cov chaw kho mob.