Cov khoom

1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine yog ib qho tshuaj sib xyaw nrog ntau yam kev siv hauv tshuaj chemistry thiab kev tsim tshuaj.Ib qho peev xwm siv cov tshuaj no yog nyob rau hauv cov tshuaj chemistry. , tshwj xeeb hauv kev tshawb nrhiav tshuaj.Lub xub ntiag ntawm pawg hydroxymethylpyridinyl qhia tias muaj peev xwm cuam tshuam nrog cov hom phiaj lom neeg, xws li enzymes lossis receptors.Cov kws kho mob tuaj yeem txhim kho cov qauv ntawm cov khoom sib xyaw no txhawm rau txhim kho nws txoj kev sib raug zoo thiab kev xaiv ntawm cov hom phiaj lom neeg xav tau.Los ntawm kev hloov kho cov phenyl thiab piperazine moieties, cov kws tshawb fawb tuaj yeem kho qhov sib xyaw ua ke ntawm cov khoom siv hluav taws xob thiab cov tshuaj pharmacokinetics, uas tuaj yeem ua rau kev siv tshuaj zoo dua qub thiab txo cov kev mob tshwm sim tsis zoo.Lwm daim ntawv thov ntawm 1-(3-Hydroxymethylpyridin-2-yl)-4 -methyl-2-phenylpiperazine nyob hauv thaj chaw ntawm neuropharmacology.Cov qauv no qhia tau hais tias muaj peev xwm cuam tshuam nrog receptors hauv nruab nrab paj hlwb, uas ua rau muaj kev cuam tshuam rau kev kho mob hauv cov hlab ntsha.Piv txwv li, nws tuaj yeem raug tshawb nrhiav los ua tus neeg sib tw rau kev hloov kho neurotransmission hauv cov xwm txheej xws li kev ntxhov siab, kev nyuaj siab, lossis schizophrenia.Cov kws tshawb fawb tuaj yeem tshawb xyuas qhov sib xyaw ua ke ntawm cov txheej txheem ntawm kev ua haujlwm thiab ua cov kev tshawb fawb ua ntej thiab soj ntsuam los ntsuas nws cov peev xwm kho tau. Tsis tas li ntawd, cov khoom sib xyaw no tuaj yeem ua rau nws tsim nyog rau kev xa tshuaj.Nws cov hydrophobic phenyl thiab methyl pawg qhia txog lub peev xwm hla lipid daim nyias nyias, ua kom nws lub hom phiaj intracellular enzymes lossis txoj hauv kev.Cov cuab yeej no muaj txiaj ntsig zoo rau kev tsim cov tshuaj uas yuav tsum tau nkag mus rau cov hlwb thiab siv lawv cov teebmeem ntawm cov phiaj xwm tshwj xeeb.Los ntawm kev hloov kho cov qauv, cov kws kho mob tuaj yeem txhim kho nws cov bioavailability, txhim kho nws txoj kev ruaj ntseg, thiab txhim kho cov tswv yim kev xa tshuaj zoo. -phenylpiperazine nyob rau hauv cov ntaub ntawv muaj peev xwm no yuav tsum tau nruj me ntsis kev soj ntsuam ntawm preclinical thiab soj ntsuam kev soj ntsuam los xyuas kom meej kev nyab xeeb, ua tau zoo, thiab noj kom tsim nyog.Kev tshawb fawb tshuaj thiab tshuaj toxicological dav dav yog tsim nyog kom nkag siab txog nws cov teebmeem ntawm cov kab mob lom neeg sib txawv thiab txiav txim siab txog qhov muaj peev xwm tsis zoo. muaj peev xwm siv nyob rau hauv tshuaj chemistry thiab kev tsim tshuaj.Nws tuav cov lus cog tseg rau kev tsim cov tshuaj tshiab, tshwj xeeb tshaj yog nyob rau hauv thaj chaw ntawm neuropharmacology thiab kev xa tshuaj.Kev tshawb fawb ntxiv yog xav tau los tshawb nrhiav nws cov kev sib cuam tshuam tshwj xeeb, kev ua haujlwm, thiab kev kho mob muaj peev xwm, ua rau txoj hauv kev rau kev muaj peev xwm ua rau kev kho mob ntawm ntau yam kab mob thiab kab mob.