β-Alanine CAS: 107-95-9 Dawb crystalline hmoov
| Catalog Number | xwm 90324 |
| Khoom npe | β-Alanine |
| CAS | 107-95-9 : kuv |
| Molecular Formula | C3H7NO2 |
| Molecular Luj | 89.09 ib |
| Cov ntaub ntawv khaws cia | Ambient |
| Harmonized tariff Code | 2924920 ib |
Khoom Specification
| Qhov tshwm sim | Dawb crystalline hmoov |
| Assay | 99% |
Cov kab mob uas tsis yog-alcoholic fatty siab (NAFLD) muaj cov kab mob dav dav xws li steatosis me me uas tshwm sim los ntawm qhov txawv txav ntawm cov lipids nyob rau hauv daim siab hlwb mus rau steatohepatitis (NASH) uas qhia txog cov rog, o, ballooning thiab degradation ntawm hepatocytes, thiab fibrosis.Thaum kawg, steatohepatitis tuaj yeem ua rau daim siab mob siab thiab mob siab rau hepatocellular carcinoma.Hauv txoj kev tshawb no peb tau txheeb xyuas peb hom nas sib txawv, A / J, C57BL / 6J, thiab PWD / PhJ, uas qhia txog qib sib txawv ntawm steatohepatitis thaum noj 3,5-diethoxycarbonyl. -1,4-dihydrocollidine (DDC) muaj cov khoom noj.RNA-Seq gene qhia tsom, tsom xam cov protein thiab metabolic profiling tau siv los txheeb xyuas qhov sib txawv ntawm cov noob / cov protein thiab perturbed metabolite qib ntawm nas daim siab kuaj thaum DDC-kev kho.Txoj kev tsom xam pom kev hloov pauv ntawm arachidonic acid (AA) thiab S-adenosylmethionine (SAMe) cov metabolism hauv lwm txoj hauv kev.Txhawm rau nkag siab txog kev hloov pauv metabolic ntawm arachidonic aci d metabolism hauv lub teeb ntawm cov kab mob qhia profiles ib tus qauv kinetic ntawm txoj kev no tau tsim thiab ua kom zoo raws li qib metabolite.Tom qab ntawd, tus qauv tau siv los kawm hauv silico cov teebmeem ntawm cov tshuaj muaj peev xwm lub hom phiaj rau steatohepatitis.Peb tau txheeb xyuas AA / eicosanoid metabolism raws li kev ntxhov siab heev hauv DDC-induced nas siv kev sib xyaw ua ke ntawm kev sim thiab hauv silico mus kom ze.Peb qhov kev soj ntsuam ntawm AA / eicosanoid metabolic txoj hauv kev qhia tias 5-hydroxyeicosatetraenoic acid (5-HETE), 15-hydroxyeicosatetraenoic acid (15-HETE) thiab prostaglandin D2 (PGD2) yog perturbed hauv DDC nas.Peb nthuav qhia ntxiv tias tus qauv muaj zog tuaj yeem siv rau kev kwv yees zoo ntawm cov kev hloov pauv hauv metabolic raws li cov ntaub ntawv transcriptomics hauv cov ntsiab lus ntsig txog kab mob.Tsis tas li ntawd, SAMe metabolism tau raug txheeb xyuas tias raug cuam tshuam vim kev kho DDC.Ob peb lub noob thiab qee cov metabolites ntawm cov qauv no qhia qhov sib txawv ntawm A / J thiab C57BL / 6J ntawm ib sab thiab PWD / PhJ ntawm lwm qhov.
